pkaral

This makes the world a better place. I got a little oxytocin hit just from the thought that somewhere on this world, someone is working on this problem. Now I'll be kinder to old ladies and give those poor puppies a pass.

I have been following GLP1 drugs for a long time, and I have a close family member who benefits. I think it is safe to say that it is hands down the most important new class of drug in ages (think milestones like penicillin). The sad thing is that it is misunderstood:

1. "It is a cure" - no, it isn't. Once you're off them, you're likely to be even less equipped for maintaining energy balance than before. So you need to stay on them, either for life or until you are really able to rework your own habits and overcome that 10(?) year period where the body is frantically pumping chemicals into your bloodstream that signal to get back to the old body composition.

3. "It is for obese people" - no, it is for everyone who struggles with energy balance in their diet. The relative availability and affordability of food that stimulates overeating means that these drugs are for a huge part - probably the majority - of the population.

Exercise and sleep have even better benefits than glp1 drugs, but that is not an argument against them.

There are so many implicit premises in that short comment, such as:

- Incredibly smart people are always right when it comes to extremely complex systems involving both deterministic behavior and human psychology - The people with the nuclear codes will be given their orders by (or themselves be) incredibly smart people - Wargames work (they have a horrible track record) - The best plans are based on a complete understanding of the starting conditions and the factors that influence the modelling (including the "unknown unknowns")

I could go on.

Great topic, and great start. Another anti-pattern I see is: "Do not file PRs on code that you hasn't been reviewed for accessibility to a human".

At first glance, this could seem to be redundant (downstream) of the suggested anti-pattern. But reviewing code doesn't necessarily mean reading all of it. A reviewer might want to unpack a function you already know well, because you specified it and saw it work (but never read).

Lots of good points. Just want to point out that this can quickly become another self improvement project with its own sources of stress, insecurity and so forth.

In Tibetan Buddhism, there is a lojong slogan: "Self-liberate even the antidote". It refers to exactly this -- the practices we use to get away from bad habits may themselves become bad habits. Rather than embarking on an infinitely recursive run of trying to stop self-improving, just don't be black-and-white about things.

One source (of many): https://medium.com/kaitlynschatch/lojong-practice-journal-se...

This is gold for those of us who dabble in adjacent things but don't want to (or aren't able to) do the math.

There are various views on Dario's communication style etc. But in this, he is the guy we have been waiting for. The guy who is willing to say: "We built this company for America, and we're going to do what we believe is right for America, regardless of short term expediency." Also called having a spine.

He has my respect for that