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nataril

5 karma · joined April 30, 2026

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nataril··on Biology is a Burrito: A text- and visual-based journey through a living cell
> For me, success means "robust structural intuition". Perhaps frame it as understanding that's robust to adversarial noise? To fuzzing testing?

There was a flurry of papers in the early 2000s that aimed to generalize biological robustness, borrowing from ideas and math from engineering. You might find these interesting:

https://www-users.york.ac.uk/~lsdc1/SysBiol/kitano.robustnes...

https://link.springer.com/article/10.1038/msb4100179

https://www.cs.unibo.it/~babaoglu/courses/cas02-03/papers/Ro...

> An Ideal Gas Law chapter problem, with numbers for solid Argon -

Ha!

> First-tier institution students, coming to intro genetics from intro bio, lacking even a firm grasp of central dogma?

Yeah, unfortunately this is a real problem: Foundational biology courses (intro, genetics, cell bio) overwhelm students with a firehose of facts that must be learned or you flunk out. Later, in upper-level undergrad and grad school, those facts start connecting, and biology becomes lots more interesting and actually easier to study.

> Are labels and vocabulary treated as foundational, or as relatively unimportant?

Vocabulary is a big deal in biology. Many terms carry associated meaning, for example polymerase chain reaction helps describe the mechanism, and TAQ polymerase reminds you that heat is important. Bone morphogenic protein says a lot.

That said, plenty of biology terms are pretty useless. Ribosome doesn't provide much intuition other than RNA is involved, and Golgi apparatus is even worse. Many gene names are arbitrary, reflecting a lack of knowledge at the time of discovery. Some are just dorky like sonic hedgehog.

Good undergrad biology books have big, carefully written glossaries in the back, these are absolutely invaluable.

> How important is seeing why things are the way they are?

It's important to internalize: 1) Biology is just physics and chemistry. 2) Millions of years of evolution and randomness produced all these arbitrary biological systems with their endless complexity. That's why living organisms are nothing like rational engineered systems, despite all the shared physics.

> If you haven't seen part of the map, how important is being able to sketch it in plausibly? If fragmented into puzzle pieces, how important is being able to fit them together?

For me, studying any big subject with lots of details, context really helps. It's easy for me to get lost in the details and lose motivation unless the ideas plug into some bigger picture. That's true even if I only want tourist-level knowledge.

nataril··on Biology is a Burrito: A text- and visual-based journey through a living cell
> engineering first-principles intro to cell bio

Very true, these books are qualitative. There's a bit of basic math around delta-G for reactions and Chi-sq tests for genetic associations, but the conventional undergraduate introductory biology course is 99% descriptive.

There are reasonable arguments for taking that approach. These courses are foundations for subsequent study, with the intended outcome that students have a broad but shallow understanding of core basic ideas. Lots of biology makes intuitive, mechanistic, and visual sense, much like introductory computer science and introductory chemistry.

Obviously applied math plays a key role in biology but it tends to address specific needs like protein structure prediction, dynamic modeling of transcription/translation and metabolism, inferring phylogeny, high-throughput 'omics analysis, network simulation of epidemic outbreaks, and so on. These are great to study, but without the broader context the understanding would be relatively fragmented, lacking the big picture.

Rereading OP's question:

> good modern starting points to someone who would want to learn more about how living beings work (from bottom up)?

I interpret that as wanting a general understanding, starting with chemistry and working upwards towards evolution and populations. That's all in the standard two-semester introductory course, hence my book recommendation.

If that's wrong and OP wants a math-centric approach, here are a few gems:

Physical Biology of the Cell, Phillips, et. al

An Introduction to Systems Biology, Alon

Evolutionary Dynamics, Nowack

nataril··on Biology is a Burrito: A text- and visual-based journey through a living cell
Get any modern undergraduate Intro Biology textbook like Campbell. These are fantastic books: beautifully illustrated and clearly written, and way better than popular science books at the mall bookstore.

The first few Units cover all the basics: chemistry of life and energy, molecular biology, cell biology, and genetics. From there you can branch out into anything.