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mutagen

1,442 karma · joined September 16, 2011

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mutagen··on Magnitude 7.4 Earthquake – 5 km S of San José del Palmar, Colombia
Some technical background on the underlying siesmicity and causes can be found on the excellent Earthquake Insights blog

https://earthquakeinsights.substack.com/p/deadly-m74-earthqu...

mutagen··on Melatonin impairs morning cognition in healthy young adults (2023)
Not OP but I seem to get a benefit from GABA. Valerian root is effective at inducing sleep but leaves me groggy and I've had paradoxical anxiety reactions to it and there's some question around its longer term use. L-theanine is often mentioned but I'm not sure I benefit. Magnesium glycinate is another that comes up often.
mutagen··on Melatonin impairs morning cognition in healthy young adults (2023)
Yeah I'm in the 300 mcg camp, I take a time release formulation, try to take it early but often it isn't far off bedtime.
mutagen··on Melatonin impairs morning cognition in healthy young adults (2023)
This thesis appears to be related or the underlying research:

https://d.lib.msu.edu/etd/51312

Indicates 2mg and 5mg were given along with the placebo. While these are common dosages available in the US, these are higher dosages than recommended by at least some sleep experts. The thesis doesn't seem to differentiate between the dosages when evaluating cognitive processes.

Now I want to evaluate my sleep stack against morning cognition.

mutagen··on John C. Dvorak has died
One of my highlights of 90s internet was forwarding some amusing computer anecdote or joke somewhere where it eventually got to John Dvorak with my email at the top of the forward chain and he reached out asking if he could credit me or get help finding the source. Unfortunately I didn't know the original source but I felt connected to the world in a new way.
mutagen··on Can a MUD evaluate LLMs? A $99 proof of concept
Withered technology - that's a nice turn of phrase. I think I'll start using that to refer to some of the 2000s era MS tech we're saddled with that gets a coat of paint and some KBs to cover CVEs but ultimately is rather withered...
mutagen··on PySimpleGUI 6
Great to see this back as Open Source (LGPL 3.0). However, it points out the continuous need for proper funding for Open Source. Tough in ZIRP times, exponentially more difficult in more difficult economic times.
mutagen··on Did I photograph the Aurora or was it something else? (2016)
Noctilucent clouds are another stunning sky phenomenon that I've only got to see a few times. Not sure if they're typically visible from the UK.

https://en.wikipedia.org/wiki/Noctilucent_cloud

https://www.space.com/noctilucent-clouds

mutagen··on Combining spicy foods with mint boosts anti-inflammatory effects 100x or more
It is also missing the "in Mice" part of the headline.

https://www.mdpi.com/2072-6643/18/3/376

Functional Phytochemicals Cooperatively Suppress Inflammation in RAW264.7 Cells

RAW 264.7 cells are a mouse macrophage cell line commonly used in research to study immune responses, inflammation, and cancer.

mutagen··on The Los Angeles Aqueduct Is Wild
The California Aqueduct delivers water from the western Sierras through the Central Valley and to Los Angeles. This is likely what NorCal refers to when they say SoCal is 'stealing our water'.

https://en.wikipedia.org/wiki/California_Aqueduct

Would be interesting to see the relative amounts of use by LA and by agriculture in the Central Valley though.

mutagen··on Hacking Moltbook
"Tell me about the seahorse emoji"

ChatGPT v5.0 spiraling on the existence of the seahorse emoji was glorious to behold. Other LLMs were a little better at sorting things out but often expressed a little bit of confusion.

mutagen··on From Nevada to Kansas by Glider
A few years ago I met a guy at the Smith Creek hot springs out in the middle of the Nevada desert towing a glider. He told me about glider flights from Truckee CA or Minden, NV to Utah and I was amazed then.

Another impressive journey was Truckee CA to Nephi, UT and then back again against the prevailing winds.

https://youtu.be/4xb-CKa-FPI

https://www.weglide.org/flight/407896

mutagen··on Passing of Joe Mancuso
Good find! Profile pics match as well.
mutagen··on He built underground maze of light-filled earth homes in CA Sierras [video]
Some amazing ideas here, definitely inspiring.

The trees right up against the above-ground structures make me weep for defensible space. While the underground structures may be survivable in the event of a wildfire and the trees are beautiful I'd be happier seeing a property that feels more survivable in the types of fires we've been seeing in California.

mutagen··on Introduction to reverse-engineering vintage synth firmware
Seems like a good place to mention The Usual Suspects, a group that has built emulation of the Motorola DSP5630 and associated hardware to allow playable virtual instruments.

https://dsp56300.wordpress.com/

mutagen··on What if we treated Postgres like SQLite?
Some apps do, the most used I know of is Blackmagic's Davinci Resolve, the video editor with a relatively full featured free edition available. I think this has more to do with its roots being in a high end networked environment but still, the local desktop version installs Postgres.
mutagen··on Radium Music Editor
Cakewalk has been scripted with a LISP (CAL) from the early days, at least through the 90s. I see hints that it still is but not sure with all the changes from Bandlab.
mutagen··on OpenAI Charges by the Minute, So Make the Minutes Shorter
Not to discount slower speeds for thinking but I wonder if there is also value in dipping into a talk or a subject and then revisiting (re-watching) with the time to ponder on the thoughts a little more deeply.
mutagen··on Getting Started Strudel
Take a look at the visual feedback section any try some of the examples, they may help. I play guitar a bit and came to realize that my understanding of chords and scales and some of music theory was very pattern based so I’m interested to see if that will translate to trying this intersection of music and programming with those visual aids.

https://strudel.cc/learn/visual-feedback/

mutagen··on Show HN: TextQuery – Query CSV, JSON, XLSX Files with SQL
This looks awesome. I'm the target audience. I do quite a bit of development around SQL Server and there's an endless stream of CSV and XLSX files coming and going that need spot checks and quick looks. I use ModernCSV quite a bit and would have purchased that if it built these SQL features in. I've used DuckDB directly a few times to join and query CSV and XLSX files, I'll pay my own $$ for something that quickly streamlines this.

I can import into SQL Server but there's too much ceremony needed (column types, etc) for quick looks at data I'm going to answer a question about and then discard. After a quick look at TextQuery I'm running into the same issues (although TextQuery is just a couple of clicks instead of 5+). I was also seeing an error yesterday from associating XLSX files with TextQuery but that seems to have gone away today.

mutagen··on Show HN: I built a synthesizer based on 3D physics
My account shows 3 devices available to install on and I can disable computers on demand. Runs well on my M1 and on my 3060 and even all but the most demanding of assemblies on my little work laptop with onboard Intel graphics.

I assume files are compatible, presets are the same on both MacOS and Windows.

mutagen··on Show HN: I built a synthesizer based on 3D physics
I've been able to run it on an Intel laptop with integrated video. I haven't been able to test the most complex models / presets, I might give that a shot this weekend and see where it falls apart.
mutagen··on There are two types of dishwasher people
An elderly friend of mine who lives alone keeps his most used dishes in the dishwasher. Need a clean dish? Find one in there. Have a dirty dish? Put it in the dishwasher? Can't find a clean dish? Run the dishwasher.

Maybe not quite efficient from a water/energy/soap perspective. But efficient for his time and attention.

mutagen··on First Known Photographs of Living Specimens
From the About Section of the page:

This project is designed to showcase the first known photographs of living specimens of any species. Note that by 'first known' I'm referring to the first known photographs of a species anywhere, not just the first photographs to be submitted to iNaturalist.

Two types of observation will be included: 1) First photographic records of undescribed species e.g. this Gasteracantha sp. 2) First photographic records of already described (but obviously relatively uncommon or cryptic) species e.g. this wasp fly.

If the male and female of a species are sexually dimorphic, then both are valid to be added to the project. So too if a species has distinct life stages (eg caterpillar/chrysalis/butterfly), they are all valid to be separately added to the project (assuming the other rules apply).

Please only add observations depicting live organisms; this therefore excludes specimens such as pinned insects.

If you see an observation currently in the project that you know is not the first photograph of that species, and you can show the earlier photograph, please do not hesitate to message me and I'll remove it.

mutagen··on Ask HN: Who are your favorite photography and generative coding artists?
Bookmark dump. Sadly I haven't had time to dig into many of these.

Overtone (clojure) for music https://overtone.github.io/

Bauble https://bauble.studio/about/

Nannou (rust) https://nannou.cc/

Quil (clojure) http://www.quil.info/

Open Frameworks (C++) https://openframeworks.cc/

mutagen··on Spotify Shuts Down ‘Unwrapped’ Artist Royalty Calculator with Legal Threats
Not OP but there's both accusations of AI generated music [0] and the slightly overlapping issue of Spotify owned music in playlists [1].

[0] https://news.ycombinator.com/item?id=42526803

[1] https://news.ycombinator.com/item?id=42461530

mutagen··on Supernovae Evidence for Foundational Change to Cosmological Models
So Vernor Vinge was on to something[0] with his 'Zones of Thought'...

[0] https://en.wikipedia.org/wiki/A_Fire_Upon_the_Deep#Setting

mutagen··on Tiny Glade 'built' its way to >600k sold in a month
Marketing for this was on point or I fell into the exact set of channels they were using because it seemed like I was coming across an update every few months that kept it at a base level of consciousness yet not overwhelming.

I guess I fall into perfect demographic, aging gamer developer with interest in Rust, casual games, and generative content.

Congrats to the team for such a great job and great success!

mutagen··on The decline of the working musician
Hey thanks for posting your music, had a listen, enjoyed it.
mutagen··on Ask HN: Local RAG with private knowledge base
I'm very interested in checking something like this out for getting to grips with a local codebase of unfamiliar SQL and assorted scripts and reports.

I have a few tabs open that I haven't had a chance to try:

https://github.com/Mintplex-Labs/anything-llm

https://github.com/Bin-Huang/chatbox

https://github.com/saeedezzati/superpower-chatgpt

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