mriet

Not. External LLMs are blocked at my company. For good reason.

Yes, by Pedro Sanchez, of Spain

Interesting, imho, more because who he is, and Spain's current role, than the actual content. Also, targeted at.. the US? Western Europe, I guess?

"Former Goldman Sachs commodities chief Jeffrey Currie said this week the real reason the oil price had not returned meaningfully above $100 a barrel in the past few weeks was not a sign of supply - which has been severely constricted by the near-closure of the Strait of Hormuz - being plentiful, but rather of what he called "capital aversion"."

Their business model is to allow as many possible "valid" transactions, not to serve their "clients". They're a PSP...

Realistically, without data from a large testset that compares this thoroughly to Samtools (and others?), I wouldn't touch this.

Note to the OP: specify a focus please? short, long, mega-long read and bacterial, human, small plant or large plant genome? Alignment heuristics and performance differ significantly across those axes.

And yet, Escape from Tarkov is not on Steam, which would seem 5o contradict what you're saying.

Wait. You built a new language, that there's thus no training data for.

Who the hell is going to use it then? You certainly won't, because you're dependent on AI.

I would argue that craftsmanship includes a thorough understanding and cognitive model of the code. And, as far as I understand it, these agents are syntactic wonders but can not really understand anything. Which would preclude any sort of craftsmanship, even if what they make happens to be well-built.

So, I respect the entrepeneurship and technical skills to make this. Well done!

That being said, this is insane.

Maintaining your social network is a skill, just like being able to swim, doing math, being able to hold a good conversation, being able to code or cook or do your taxes.

The "promise" and "illusion" of silicon valley is that all problems (including and maybe even especially social ones) can be solved with technology. This is not true.

Having to use your brain to think about things is definitely painful. It also has incredibly good long-term effects -- and also negative short-term effects because it costs energy. It's similar to eating well, regularly exercising and other aspects of taking care of yourself.

Making sure you can remember to think about other people is not a problem -- it's a REALLY valuable skill that is gradually disappearing.

Lots of mayo.. and butter. It's more like a butterich, realistically. ;)

I'm already having flashbacks of how the tobacco industry faired..

Think about moving. Job markets are vastly different geographically and have been for some time.

It's kind of weird that Romania has done so well, given that amount of turmoil in Romanian politics and Romania in general in the last 20 years.

Basically, it went up for Romania because they got access to the EU market (in terms of both exports and remittances) starting in 2007 and that helped, _despite_ everything else that went on. So.. kind of a win for Romania and the EU, I guess.

Idiotic and massively overlooks/underestimates how complex biology is.

What about beneficial and neutral but important bacteria and viruses? "Air" is actually a complex soup of all types of things. This like applying HCl to a skin infection.

Take theater classes. Or join a (team) sports club. Both teach you skills that you most likely will not acquire elsewhere and that are directly applicable to interviews.

Also, having been on both sides, I can tell you that hiring is just a crap shoot. My (anecdotal!) experience is that a lot of hiring is e8ther 50% gut feelings-based or 50% keyword-based. And in the worse case, both.

I can understand this for "small" data, say less than 10 Mb.

In bioinformatics, basically all of the file formats are human-readable/text based. And file sizes range between 1-2Mb and 1 Tb. I regularly encounter 300-600 Gb files.

In this context, human-readable files are ridiculously inefficient, on every axis you can think of (space, parsing, searching, processing, etc.). It's a GD crime against efficiency.

And at that scale, "readable" has no value, since it would take you longer to read the file than 10 lifetimes.

Further down in the discussion, he also adds this comment, which is also good:

https://github.com/Cyan4973/xxHash/issues/229#issuecomment-6...

This comment on github, by Yann Collet (of zstd fame), is the most enlightening, practical information about the practical uses of hashes and checksums that I've seen about hash collisions. I highely, highly recommend it:

https://github.com/Cyan4973/xxHash/issues/229#issuecomment-5...

See "Debt, the first 5000 years" by Graeber.

Debt exists because of (the threat of) violence. Money exists because of debt (.. is in fact debt). Modern society is based on our monetary system.

I worked as an open source developer (remote) between 2011 and 2016. At the end, my social skills were deteriorating (despite a reasonable social life and hobbies) and I was less motivated, disciplined and less productive.

I now work at a company where there are a max of 6 people to a room. I would go in every day except that I have a small child and it's easier in terms of logistics to work at home one day a week.

I am a hardcore introvert. I am not shy and have worked successfully as a manager (and hated it). If you think introvert == shy, look up the definition of introvert. I know several extroverts with significantly worse people skills than me.

Working at the office: - motivates me - makes me happier and less lonely - makes me more productive -- *in the long run* - helps me (a lot) with networking and generating new projects.

While working in open source, I ran into many developers who had been working at home for between 10 and 30+ years, and were very productive. Some people can do this. You must have a thick skin and be stubborn or otherwise single minded -- and it helps if you are not single.

However, I believe that the majority of people will initially be productive when WFHing, for the first 1-5 years, after which a steady decline in both productivity and mental health will set in.

Research has conclusively shown that your social network is directly related to both your health and happiness. The line between this and WFH is really short....

Agree fully with recruiters being BS.

Google keyword alerts/searches and/or word of mouth, although the latter is less trustworthy. Search, goshdarnit!

Have also randomly contacted a few people in my LinkedIn network for advice at 2 times in my career, in order to get more knowledge about skills, industries, company landscapes, etc.

Spent basically 19 years doing enterprise software dev for your typical slew of companies: logistics, banking, fintech, retail, etc. After a particularly unpleasant startup experience, decided that 1) recruiters are BS and 2) I wanted to work on research related problems, because they were probably the most technically and intellectually challenging. Spent 2-3 months really looking for a job, and found a hidden gem. I earn basically 80% of what I earned 6 years ago and probably something like 70% of what I could be be earning elsewhere. My salary will grow very slowly compared to elsewhere.

The work and people are amazing. I learned more in 1 year then the last 10 and just really like my work. The pace and culture is levels orders nicer than the corporate or startup world.

At some point, hopefully we'll also figure out how to get AI to catch itself when it makes bugs. This will also be an important skill.

Or otherwise to recognize what type of bugs the AI will make -- like the way you know what type of bugs junior engineers will make.

I think there's a good chance of there being some really bad bugs/system failures in about 25 years because of this.

"AI can do code" -> less experienced engineers -> no one has deep understanding of the whole system -> boom.

But it will take 25 years before this series of events plays out.

Wow. The reviewer/writer manages to completely miss some of Graeber's key points.

The reviewer writes "That some questions about inequality are obscure or ill-framed does not indicate that inequality of wealth is not a fundamental social problem."

Graeber's point about inequality is that, as a rights concept, it's impossible to define, and also not a good representation of how good communities work.

The reviewer is bending Graeber's words to suit his own points (and publications!). "Inequality of wealth" is a redundant misconception for Graeber, since wealth == inequality.

Couldn't agree more. Thank you for saying this.

This duplicates research that is at least 20 years old.

Also, depressed people (and people with similar mental conditions) resist sleep also partially because being tired means that you feel less, and thus are relieved from the pain you feel more acutely when more awake.

Exactly! Ironically, dvc doesn't really scale well and is limited to small-ish files.

Wonder if he tried zstd --long=31

Or, given that he's basically mentions FCM/PPM, zpaq.

Sounds like it's related to Graeber's book, "Debt, The First 5000 Years".