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merqurio

661 karma · joined October 31, 2014

Medical Doctor and Mathematician. computing & statistics geek
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merqurio··on Kev: Tiny Jev-like family of decision models built on top of Qwen3.5
Shouldn't Jev-like models be built on top of diffusion models ? like GSAI-ML/iLLaDA-8B-Instruct ?

That showed us the best results at least

merqurio··on Stripe to Buy OpenRouter for $7B
If LLM providers continue grow and become such a standard part of the tech stack of any deployment, this acquisition makes a lot of sense. It's just another payment management system for stripe.

It's fun to see someone being able to exit so well without owning any model.

merqurio··on Cargo-nextest: 3x faster than cargo test, per-test isolation, first-class CI
Happy user here !
merqurio··on Math Is Hard – OpenBSD Stories
The lack of vertical integration in the modern stack is surprising. We’ve spent 30 years treating the UNIX paradigm as the "end of history," while burying ourselves in layers that add zero mechanical value.

I initially thought the containerization movement of the early 2010s would be the first step toward redefining the OS—a way to finally slim things down. Instead, it just became a more efficient way to pack up the same baggage. We created a "reduction" in deployment complexity, but we haven't seen a continued effort to use those tools to actually change the paradigm.

I expected vertically integrated systems to become the norm by now—where building an executable would be an experience similar to containerization, but resulting in a lean, data-centric unikernel.

Instead, we are burning CAPEX on YAML sidecars in K8s clusters and N-tier abstractions that exist solely due to the large heterogeneity of the deployments that they never should have entered in the first place. We are spending more energy on the friction between layers than on the actual business of computation.

I was hoping for a return to sanity with the DBOS [1] research, looked like an attempt to rethink systems from first principles. But it seems that effort hasn't fully kicked off in the way the industry desperately needs.

[1]: https://dsail.csail.mit.edu/index.php/dbos/

merqurio··on My Journey to a Datacenter in a Box
Hi HN, author here.

After my old homelab laptop died, I decided to over-engineer its replacement.

A question for the homelabbers and infra folks here: Do you actually find value in people open-sourcing their personal infrastructure repositories?

All of my configurations are currently in a private repo because they feel too customized to my specific environment (domain names, specific storage tags, etc.) to be useful to anyone else. Have you ever genuinely learned from or reused someone else's opinionated personal configs?

Happy to open mine up if people find that kind of reference material helpful.

Also happy to answer any questions about the Turing Pi hardware or the Talos experience!

merqurio··on An analogy for Machine Learning: It's like baking a cake without a recipe
Hi HN, the author here

I wrote this post after giving a talk on AI to a non-technical audience. I found that the analogy of baking a cake without a recipe was a powerful way to build intuition for how ML models are trained and, more importantly, the common ways they can fail.

I hope this is a useful mental model, whether you're an expert trying to explain your work or a newcomer to the field.

I'm here to answer any questions.

I'm also curious: what are your favorite analogies for explaining complex technical topics?

merqurio··on Show HN: Coi – A language that compiles to WASM, beats React/Vue
Nice work ! Thanks for shating

It reminds me of https://leptos.dev/ in Rust, although the implementation might be very different

merqurio··on Fossil versus Git
If you want to understand the implementation, the DeepWiki documentation is very helpful:

https://deepwiki.com/drhsqlite/fossil-mirror/

merqurio··on Europe is scaling back GDPR and relaxing AI laws
The news feels bittersweet. With 10+ of experience in healthcare AI, I have seen enough shitty products to genuinely welcome strict regulation for critical sectors; however, this shift threatens to dilute the sense of urgency that was growing in the sector.

We recently built a platform specifically to navigate the complex intersection of MDR (Medical Device Regulation) and the AI Act, relying on the pressure of hard deadlines. By introducing flexible timelines linked to technical standards, the EU risks signaling that compliance is a secondary concern, potentially stalling the momentum... and at this point patient safety is my biggest concern, not our platform

This introduces chaos rather than relief. Companies do not need lower standards; they need clarity.

We can compete effectively against high standards as long as the rules are clear. EU AI Act was clear. This proposal substitutes the certainty of a high bar with the confusion of a sliding scale, which may hinder the industry more than it helps :/

merqurio··on LaLiga's Anti-Piracy Crackdown Triggers Widespread Internet Disruptions in Spain
i've been trying to understand what was making the CI fail for about 3h, until i realised it was this thanks to this post.

thanks. this sucks.

merqurio··on Europe 'not in the AI race today,' French President Macron says
Macron’s focus should be on making sure that France’s existing AI successes like Mistral, Owkin, and Bioptimus have the right business environment for scaling and internationalizing, closing big initiatives with big corps/institutions rather than launching yet another public-sector initiative. These startups already demonstrate France’s AI potential, but they need strategic support to compete globally. Instead of reinventing the wheel with new government programs, why not double down on making these companies world leaders?
merqurio··on 7 Databases in 7 Weeks for 2025
FondationDB is such an incredible resource, but it’s so hard to access for the general public. It’s no wonder so few people know about it. I’ve always thought that if there were easier ways to interact with it, or some dev-friendly layers built on top (or public) it would become way more popular. it has shown how well it scales with Apple and snowflake, but is not an obvious choice for non-internet scale applications.

If you don't know about FDB; there's an amazing video about how they test it that really got me into learning more:

https://youtu.be/4fFDFbi3toc?si=9g3hZogBq3Ou25xZ

merqurio··on OrioleDB beta7: Benchmarks
All my kudos for the OrioleDB team, they have been working for years with the Postgres core devs to get the extensibility patches they need for their storage extensions merged back.

It’s not just about building their extension but actually making Postgres better for everyone. I would have loved that big corps would have taken this approach, as it opens the doors to others to add features for different use cases and making postgres more of a DBMS framework

merqurio··on Ask HN: Are you using SQLite and Litestream in production?
i'm using a personal project , so far, it's been great. The code is easy to follow and the author AFAIK, he was working on an employer (Fly.io) that is giving him time and resources for litestream.

I would adventure to use it in a small production environment if you can have user/customer based sharding of sqlites and then have a clickhouse/postgres for multiuser analytics store.

merqurio··on Ask HN: Who is hiring? (January 2022)
IOMED | Data Engineer | Barcelona, Spain | Full Time | Onsite

Are you looking for a job with a direct impact on healthcare?

  * Problem: Clinical data is messy and makes research slow.
  * Mission: To structure clinical data and give unified, standardized access to it.
  * Product: Natural language processing models and a unified SQL data access interface for researchers.
  * Traction: Validated idea, Validated business model, growing and scaling stage.
  * Funding: +2y runout and growing. Backed by national and international VCs.
  * Stack: Python, Cython, SQL, Postgres, Kubernetes among others
  * Values: Scientific, methodic, transparent, hard workers with a HUGE emphasis on work-life balance.
Join a multidisciplinary team working hard to make clinical research faster, accessible and ubiquitous. Also it's a nice excuse to enjoy Barcelona's vibe and nice weather !

Want to know more? Ping me at g@iomed.health or check our site for more info https://iomed.health/en

merqurio··on Zanzibar: Google’s Consistent, Global Authorization System (2019)
There is an Open Source (Go) implementation of "Zanzibar" called Keto [0] that integrates with the rest of the Ory ecosystem. We are actually testing it and looks great so far.

[0]: https://github.com/ory/keto

merqurio··on High schooler invented color-changing sutures to detect infection
Similar ideas are already patented [1]. I appreciate the simplicity of her approach, but I'm not sure if she would be able to create a business. I hope her the best.

[1]: https://patents.google.com/patent/US20090142275A1/en?q=Infec...

merqurio··on Ask HN: What low-code “dashboarding“ SaaS would you recommend in 2021?
I recently evaluated a bunch and https://github.com/appsmithorg/appsmith covered our needs. For building internal tools seems like a great alternative.
merqurio··on Casio Graphing Scientific Calculator Fx-9860GIII Comes with MicroPython
I have one and I encourage anyone looking for a modern calculator to buy one. One of the best purchases I have ever made. Happy to answer any questions.
merqurio··on How io_uring and eBPF Will Revolutionize Programming in Linux
Also from Glauber Costa, a thread-per-core framework using io_uring written in Rust[1] and discussed in HN[2].

[1]: https://github.com/DataDog/glommio [2]: https://news.ycombinator.com/item?id=24976533

merqurio··on Ask HN: Who is hiring? (November 2020)
Up to the candidate. Pre-corona it was onsite.
merqurio··on Ask HN: Who is hiring? (November 2020)
IOMED | Database Developer| Barcelona, Spain | Full Time | Remote

Are you looking for a job with a direct impact on healthcare?

* What we are looking for: An experienced database developer willing to keep pushing forward the boundaries of Postgres.

### About the company

* Problem: Clinical data is messy and makes research slow.

* Mission: To structure clinical data and give unified, standardised access to it.

* Product: Natural language processing models and a unified SQL data access interface for researchers.

* Traction: Validated idea, Validated business model, growing and scaling stage.

* Funding: +3y runout and growing. Backed by national and international VCs.

* Values: Methodic, transparent, hard workers with a HUGE emphasis on work-life balance. Join a multidisciplinary team working hard to make clinical research faster, accessible and ubiquitous.

Also it's a nice excuse to enjoy Barcelona's vibe and nice weather!

Want to know more? Ping her at julia@iomed.health, she's awesome. Check our site for more info https://iomed.health/careers/database-developer/

edit: formatting

merqurio··on On Abandoning the X Server
Thanks for sway!! It's my favorite compositor by far
merqurio··on Ask HN: What is your passive income 2020?
I really like the idea of a Marketplace for side projects. I have had a couple of side projects myself and sometimes they died because of the lack time or resources even if they had some traction.
merqurio··on Ask HN: What is your passive income 2020?
I love the idea of providing a platform to share rage/frustration or whatever in such a raw mode, without the destructive/negative comments. Just pure emotions.
merqurio··on Ask HN: Who is hiring? (October 2020)
IOMED | Frontend Developer| Barcelona, Spain | Full Time | Onsite

Are you looking for a job with a direct impact on healthcare?

* Problem: Clinical data is messy and makes research slow.

* Mission: To structure clinical data and give unified, standardized access to it.

* Product: Natural language processing models and a unified SQL data access interface for researchers.

* Traction: Validated idea, Validated business model, growing and scaling stage.

* Funding: +3y runout and growing. Backed by national and international VCs.

* Stack: React, redux, saga, typescript, REST and GraphQL APIs, Postgres ,Docker, Kubernetes

* Values: Methodic, transparent, hard workers with a HUGE emphasis on work-life balance. Join a multidisciplinary team working hard to make clinical research faster, accessible and ubiquitous. Also it's a nice excuse to enjoy Barcelona's vibe and nice weather!

Want to know more? Ping me at julia@iomed.health Check our site for more info https://iomed.health/en/careers/

merqurio··on Ask HN: Who is hiring? (October 2020)
I work here. Happy to answer any questions.
merqurio··on PostgreSQL 13
I heard someone say the other day that they would skip this version and wait for the next one. Just because of the version number. I found it somewhat sad and very poor judgment, but after thinking about it on my way to home, I think a lot of people will do the same.

It would be interesting to keep an eye on the number of downloads from containers and packaging systems to see if this is the case.

merqurio··on Is anybody still using Windows 95?
An isolated LAN and no USB peripherals. There's a wireless network with internet but no device has access to both.
merqurio··on Is anybody still using Windows 95?
I help to maintain an isolated network of desktops running Windows 95. It's a complex EHR system with multiple clients.

It's a family business, and the software works really well (a medical niche), so the investment to update the stack doesn't make any sense. (And there's no need to bother clinicians neither with things that don't add value) I have a VM for tweaking and working with it. I have multiple ETL scripts that extract the data to a modern ERP.

I don't have access to the source code, but I have tried to reverse engineer it from multiple angles. Essentially it's a 16 Bits client written on Delphi with a database (dBase) that doesn't support multiple readers or writers, shared via a network drive. Clients read files from the shared drive and create locks to avoid multiple clients working in the same data. That's the main source of pain, but the clinicians adapt to it in a week or so.

I haven't seen yet a modern system as complete as this one. There are multiple clinical centers in the area using the same software (25ish) and the 2-3 that moved into newer systems regretted greatly.

The market is too small for any new developments. But the guy who built it in the 90's maintains it and earns enough to live happily.

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