Not sure if you'll see this comment since it's been a week, but how did you find this out? Is 3.5 Pro officially cancelled internally? Are they only working on 4 Pro now?
9,350 karma · joined May 2, 2017
For decades, the industry standard was to hunt for targeted small molecules to solve singular biological issues. And to be fair, I don't think this was because of a lack of vision as it was simply the strict limit of our technological capabilities at the time. But attempting to treat a cascading, systemic disease like Alzheimer's with a single targeted molecule is like hoping replacing one pipe will solve the problem when the issue is that the entire plumbing system is corroding.
This fundamental mismatch is exactly why clinical progress has stalled, and I believe the future of treating Alzheimer's will instead closely mirror how our approach to oncology has evolved.
We spent years searching for a universal molecule to cure cancer before we accepted reality. We now know that effective treatment often requires sequencing a tumor's mutanome to develop a highly personalized intervention for the individual. As neurodegenerative systems fail with age, we face that exact same biological complexity. A traditional small molecule is not going to rescue a globally failing network.
My personal take is that we won't see a true breakthrough in Alzheimer's until capital fully rotates out of these legacy, single-target pipelines and into programmable biological systems.
Popular in martial arts and Buddhist philosophy, I think practically what you should take away is that body and mind are fundamentally intertwined.
Introspection is a practice of the mind, specifically cognition centered around portions of the brain like the prefrontal cortex. There’s a lot more to who you are and areas you can hone / cultivate.
The HN crowd is probably overweighted on cognition, and could do with spending more time in other areas: https://www.cheltenhamzen.co.uk/writings/gut-instinct
Too easy to forget that there are ~10 billion people in the world. I live in the US, and it always gives me awe when I realize we represent <5% of humanity.
Good luck to Stripe though. Building the network effects necessary for an L1 is very difficult.
Jhanas (when in the positive direction), and dukkha or suffering (as caused by tanha or tension) when applied in the negative direction.
I ended up going to my local Walmart to try one, and boy was it delicious! Sometimes things work out in life.
Not everything is always surface level.
The consistent gravitation toward consciousness exploration, existential questioning, and spiritual/mystical themes in extended interactions was a remarkably strong and unexpected attractor state for Claude Opus 4 that emerged without intentional training for such behaviors. We have observed this "spiritual bliss" attractor in other Claude models as well, and in contexts beyond these playground experiments
This should bring great ease to those worried about AGI alignment.
You have to remember that for about a year and a half, everyone thought Solana was dead / doomed to fail.
Personally, I think Solana does the best at balancing the original cypherpunk ethos while ultimately driving towards the future with crypto being the rails for natively programmatic global commerce.
Consumers right now only get monetized. They see zero return from their attention being taken away from them.
Model Context Protocol seems good enough to me.
Defining the reward function, which is basically what ARC is doing, is 50% of the problem solving process.