kxs

They trained on 170k sequences/ structures/ proteins, each sequence has 10s to 100s or even 1000s amino acids. Structure is much more conserved than sequence. Out of the 100 targets, roughly 1/4th have no similarity to known structures, so there shouldn't be an overlap for those with the training set. They did very well on those targets.

There are different categories of samples, namely FM and TBM targets. FM targets don't have any similarity to known structures. Roughly a quarter were FM targets. I think the more interesting thing to look at is the size of the multiple sequence alignments (MSAs) which is the basis of this and essentially all methods. They seem to do very well with few MSAs, which bodes well for other targets, although there are families of proteins with few MSAs.

But of course that cost would only be for the final model. Anyway, I think I am just living in a different world... :-) We could never compete with that

There are other experimental methods that are much cheaper that can be used to assist validation. Also the models look damn impressive, even down to the sidechain packing.

How do you define enormous? "It uses approximately 128 TPUv3 cores (roughly equivalent to ~100-200 GPUs) run over a few weeks". Also last time it took about a year for good replications to pop up.

The targets are completely unknown. They were experimentally solved, but not submitted to the Protein Data Bank. You basically get a target every day (meaning sequence of amino acids) and then depending on the category, you have three days to predict it (I think upto two weeks for "human" servers). In the modeling category they participated in, you can submit 5 models. A model is a fully predicted 3d structure of the protein. The targets are mostly independent. Some targets were split over a few days. But in principle, a target on day X has no connection to a target on day Y. The targets have varying difficulty. There are two categories: TBM (templated based) and FM (free modeling). You don't know which protein corresponds to which category, you can just guess by looking at the available template data. They focused on FM targets. Meaning there are no homologous available. It's hard to say how good of an indicator the results are. Looking at the contact prediction results, many methods are getting very good at constructing MSAs (gathering similar sequences). We already saw this at CASP12 - I think the FM targets are getting "easier" in that sense. There is basically zero feedback throughout the whole competition. Some targets are released after the deadline (because of publications), but in general, you don't know anything until the CASP meeting, which currently takes place. The competition ended in August.

Did the supplement contain pepper? AFAIK you need to consume turmeric together with black pepper to make it effective (blocks something in the liver IIRC). Maybe that was the reason?

This was interesting: https://teslamotorsclub.com/tmc/threads/elon-musk-vs-short-s...

I used to get a lot of sinus infections, to remedy this, I drank for an extended period of my life cooled "onion juice" (onion + water + honey, cooked for ~1h). My whole family was disgusted by it, but I somehow enjoyed it.

Did it resolve your Alopecia?

I'm very interested in fasting. I have been doing IF for 4 months and it works out great. Has anyone experience with prolonged fasting (3 days+) and auto immune diseases, specifically Alopecia?

What is your initial impression?

Has been featured in the recent episodes of The League on FX as well.

You should look into Debug.Trace for quick printf-like debugging. Usage: trace ("error occurs here") (f x)

Apparently: https://tox.im

It seems to be possible to use the Chrome PDF Viewer. This could be nice for LaTeX development.

I detect mild arcasm...

Although I haven't tried Windows 8 yet, I had the same experience using Windows 7.

It's interesting that only 7 years ago you probably wouldn't have be able to sit me in front of a Windows machine without resistance or at least some complaining. Since then I turned out to be a frequent defender of Microsoft in my surroundings and I'm considering ditching my Apple ecosystem for Windows 8 (esp. because of Surface and Windows Phone 8).

But the real problem, as have stated other, is OEM software and 3rd-party-apps. It takes effort to maintain your system (although not much, at least in my opinion, but you have to pay attention to, for example, what is installed along the way). I usually have none of the problems my peers or friends have (with Windows) and if you look at their machine, you'll see why. Almost every time I visit my father, there is a new (worthless) toolbar installed.

I'm interested as well.

I've been using my HHKB for at least 8 years and I love it. But I'm thinking about switching to the Apple Keyboard because of the thickness of the HHKB, which, it's at least my feeling, is hurting my wrists. But I don't like the wireless-aspect of the Apple Keyboard...

I feel the same way, my problem is it usually starts while I'm learning a new language, so I might drop the current to pick up another, which I of course drop again etc. pp... I'm learning Haskell atm which seems to be the first language that captures my interest even after months. (the announcement of Julia made me think of dropping it, though)

Thanks, my fault, I mixed it up with "Clear Browsing Data".

Do you use an extension in Chrome to do this or surf permanently incognito? I was under the impression that it's not (yet) possible to do so automatically in Chrome (vanilla).

Well, in Germany it usually takes at least 3 to 6 months and those are mainstream series like Desperate Housewives or Grey's Anatomy.

Same here, I don't watch dubbed television shows/movies. The only alternatives are TNT and FOX atm, at least with sky you have dual audio.

Let's hope tv series like "Touch" have success with their approach, Kiefer Sutherland said they are aiming for a 3 three day window (global broadcast).

Sorry to hijack, but has anyone been able to do similar for wolfenstein: enemy territory (on OS X Lion)?

I don't own a MBP, but my mac mini (2.5ghz i5) is heating up pretty quickly (about 20-30 degrees warmer while playing a flash video).