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> methamphetamine and d-amphetamine produced similar effects on the majority of physiological and behavioral measures. Both drugs enhanced ratings of euphoria and mood, increased cardiovascular activity, and improved psychomotor performance. Methamphetamine did, however, engender greater effects on some measures (e.g., heart rate and ratings of ‘high’).
and
> methamphetamine and d-amphetamine (50 mg/70 kg) similarly increased drug self-administration; regardless of amphetamine, participants chose approximately 47–50% drug. This is consistent with results from the preclinical literature indicating that rats and rhesus monkeys self-administer both amphetamines at equivalent rates
Furthermore, your science is not quite correct. Amphetamines are a synthetic derivative of phenylethylamine (found in chocolate, cheese, and wine) that adds a methyl group, which allows it to persist in the bloodstream and therefore cross the blood-brain barrier. Methamphetamine adds another methyl group [1][2], which allows it to survive in the blood longer, cross the BBB more easily, and also makes it significantly more neurotoxic [3] because it even harder for the body to break down. Are there differences? Yes. Are they significant? As someone that has experimented with both substances, I found them far more similar than the media would have you believe.
[0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475187/
[1] https://methoide.fcm.arizona.edu/infocenter/index.cfm?stid=1...
[2] https://www.researchgate.net/publication/229653571_Speed_Ecs...
[3] https://www.quora.com/What-role-does-the-methyl-group-in-met...
I'm not primarily a JS developer, but I guess I just assumed NPM was run by a non-profit foundation like the Python Software Foundation runs PyPi. So I started looking into the governance of other significant library repos. Homebrew actually sets a good example[0], with a clear governance structure. On the other hand I have no idea who owns RubyGems.org, perhaps a loose collection of GitHub users called the RubyGems Team [1]. Maven Central (Java) is owned+operated by Sonatype [2], Packagist (PHP) is owned+operated by Private Packagist[3], Nuget (C#) is unsurprisingly owned+operated by Microsoft, and CPAN seems to be governed by the Perl Foundation. According to modulecounts.com, NPM has more hosted packages than any of the others. It's also the only one where the registry source code does not seem to be publicly available, and there are very few full mirrors that don't just proxy upstream to npmjs.org. Yikes.
[0] https://docs.brew.sh/Homebrew-Governance
[1] https://rubygems.org/pages/about
https://www.forbes.com/sites/startswithabang/2017/02/28/is-d...
http://www.astronomy.com/news/2018/05/the-case-against-dark-...
The Mormon Church spent $35 million on a printer's manuscript of The Book Of Mormon in 2017. [1]
Bill Gates spent ~$30 million on Da Vinci's Codex Leicester in 1994, which would be around $54 million today.
Even talking about printed works, The Bay Psalm Book was sold for $14.2 million in 2013.
Depending on your definition of "book", the oldest known books are things like The Etruscan Gold Book, The Nag Hammadi codices, the St Cuthbert Gospel, etc.
[1] https://www.huffingtonpost.com/entry/mormon-church-drops-35-...
I just can't quite get over this stat they dropped in here. 15 million people in ~250 AD puts it in the same neighborhood as ancient Greece at their peak a few hundred years earlier.
https://www.infoq.com/presentations/Null-References-The-Bill...
Her original goal was to improve literacy rates. Targeting children under 5 seems like a strange way to approach this. Reading to your kids is great, and there is some evidence it might help, but if you want kids to read then getting great books into hands of 5-10 year olds seem like it would help more.
Despite coming from a very well-read family, and having been read to at an early age, I resisted reading at a young age. I just wasn't interested in it, and preferred doing other things. It wasn't until 4th grade where I found a copy of 'A Book Dragon' somewhere and fell in love with it. Despite probably being above my reading level at the time, I struggled through it and then went on to devour just about every fantasy book I could get my hands on, becoming an avid general reader in the process. The right book can really make all the difference.