123 karma · joined February 28, 2017
On a side note I wish there was a way to communicate with (good) physicians asynchronously (via text for exemple) for non trivial issues, or something that allows them the time to research and think about an issue, which you don’t have the time during a consultation, without waiting months before the next appointment. Some try to get up to knowledge and read in front of me but, it doesn’t takes them more than 1 mn so they often have a shallow understanding. I’ve also met terrible ones who where annoyed that I knew more about the subject than they did and discouraged me from doing my own research (even from cochrane and serious meta-analysis), but I guess it is more a problem of the hubris of some french doctors than a process one (accordingly most of my issues stems from the fact that it is difficult to reliability avoid ignorants, that doesn’t care, or arrogant physicians that I could book, more than any other issues including software).
Same for me with Le roi et l'oiseau and Peter and the Wolf by Disney.
I think a more realistic clinical approach is astrocytes to neurons reprogramming using vectors like AAV9 to pass the blood brain barrier and activate genes to convert them [1] to different types based on the genes (NGN2: glutamatergic, ASCL1: GABAergic, dopaminergic, cholinergic...). This has the added benefit of reduced cancer risk (direct reprogramming) and astrocytes have a regional identity [2].
[1]: https://www.embopress.org/doi/full/10.15252/emmm.202114797 [2]: https://www.science.org/doi/full/10.1126/sciadv.abe8978
On the contrary, it confirms it, it means some individuals for the overall replication success of the genes they are constituted of, will sacrifice themselves.
In the book from which this theory have been popularised, the exemple of bees stinging like kamikazes is given.
[0]: https://en.wikipedia.org/wiki/Single_system_image [1]: http://linuxpmi.org [2]: criu.org [3]: https://man.dragonflybsd.org/?command=sys_checkpoint§ion...