1,253 karma · joined February 7, 2023
You are not really thinking this through. How would a fitness reducing mutation become a feature of a genetic line in the first place in asexual reproduction? The "silent" partial carrier dynamic of genetic defects is a problem exclusive to sexually reproducing organisms.
How can sexual reproduction "get rid of them"?
Play it out for a few generations, you will see, there is a frequency equilibrium. We've done this in school with paper, but if you know some programming, it's an easy exercise. Anyway, unless being very detrimental for partial carriers, the bad allele is gonna stay in the gene pool.
Apart from that, it's also wrong because sexual reproduction did not get rid of anything. Just one offspring not affected, but the premise already established the fitness of partial carriers, so that mutation is gonna remain in the gene pool.
Last time I checked, Big Biology was kinda unique going beyond basic popsci, while still remaining interesting and engaging. I think biologists are not the most technically inclined, not really drawn to podcasting. And it's also not the hottest of topics right now, specific research PR and educational voices aren't funded well. There are some journal/university etc. associated everybody-has-a-podcast-now podcasts, but I found them to be rather boring and dry. Individual episodes of the Huberman/Lex Fridman type edgelord podcasts may also be occasionally interesting, but the signal to noise ratio is poor, with a heavy bias towards overconfident and narcissistic guests speaking with false authority, lots of explanatory speculation presented as facts, pronounced political confirmation bias.
Maybe take a well presented episode on Big Biology and see where else respective guests speak or publish?
I am not a biologist, so I can not refer to or evaluate any meaningful recent papers on the matter. However, I can recommend the podcast 'Big Biology', which dives into current biology research, theory and philosophy, including sexual evolution.
You may start here: https://en.wikipedia.org/wiki/Evolution_of_sexual_reproducti...
Richard Dawkins' 'The Selfish Gene' is also an excellent read/audiobook. His specific theories of the evolutionary "unit" have been disproven, but his argumentation teaches a lot about "evolutionary thinking". I really wish he stuck with biology and science education instead of becoming this reactionary giga twat.
Caloric restriction etc. just aids cellular housekeeping. The processes in maintaining gametic immortality are much more radical and transformative. Somatic and gametic genetics are governed completely differently.
Early embryogenesis seems to activate weird genetic pathways, whose function scientists suspect evolved for the sake of complexity alone, to be a genetic integrity stress test.
Mind you, mutation in sexual reproduction isn't at all just accidental "bit flips". The cross-over stage in meiosis always recombines the chromosomal information randomly (to increase environmental adaptability, off-setting the slow rate of sexual reproduction). There is no concept of a "gene" there, the cuts can happen in the middle of anything important, too. This intentional instability needs to be accounted for, biologically.
Before anyone even detects pregnancy, a lot of non-viable genetics have been aborted by the body. As tragic as they are for the becoming parents, miscarriages are a good thing, not misfortune. It's exactly this fail-fast selection process weeding out failed random recombination attempts, which likely would have caused severe functional problems later anyway.
The body isn't a lump of omnipotent cells, but a complex system of functionally primed cells. You cannot do a selective genetic stress test on a developed organism like that. Without radical selection, the rejuvenation process wouldn't be safe, rather a guarantee for cancer and metabolic dysfunction. At any point in time, there are malignant cells somewhere in the body, which are constantly snatched by the immune system. In fact, "rejuvenation"/immortality is a hallmark of cancerous transformation. And let's not forget, embryonic development isn't fully self-governed. The mother's body also checks the embryo's signaling and may abort anything funky. A developed organism doesn't have this external oversight. Auto-immunity and genetic checkpoints is all there is and those mechanisms can become malignant, too.
Did you know, with age, men's somatic cells increasing lack the whole Y-chromosome? It's not at all mission critical and just got lost at some point during mitosis, no biggie, but I think it shows the extent of accumulated genetic disarray in somatic cells.
So part of the magic of that aging reversal is simply abandoning what doesn't stick. You can't do that to a grown human, obviously.
This annoys me so much. Everyone is acting as if the model went rogue, when it really did exactly what it's been trained for. This story is so fucking engineered.
A similar example: The melanocytes in the skin originate from the neural crest, not the epidermis. As a significant consequence, melanocytes share cell attributes with neurons. One of these attributes is the ability to infiltrate other tissues. Because of that, malignant transformation of melanocytes has vastly different consequences, compared to epithelial cells. If you asked your doctor why squamous cell cancer and melanoma have such different prognoses, describing your skin as effectively "two organs" would be illustrative and easy to understand, without getting into developmental biology.
Yes. Assuming you are young and haven't had such experience.
The world is changing not just because of AI. Everything is unstable right now. You may regret not enjoying the remainder of stability and economic viability prior generations had. It's not like you can expect to get ahead by powering through education. Either your career perspective will soon change for the better, or worse. In any case, you gain little by sticking with career building at this moment in life. You are however, at risk of losing the chance to experience the still mostly pleasant world as is.
That said, of course some important components can't really be protected passively. E.g. comms and sigint will always have expensive, hard to replace antenna arrays exposed. But narrowing vulnerability down to those assets means you can focus scalable air defense and EW measures there.
Again, this benefits the country on the defense, especially against distant enemies, since you can build bunkers etc. at home, but can't really bring them along. And bunkers are one time investments, theoretically good for centuries (WWII/Soviet bunkers are still all over the place in Europe). I think, it would be viable for a peaceful country to almost entirely invest military funds in bunkers, drones, drone comms and crews/AI, and possibly nukes, to discourage any aggressor, while minimizing peacetime running costs . Additionally, highly decentralized renewable energy like solar and wind makes that sectors really hard to disrupt. Especially individual solar installations, battery storage and electric cars potentially enables quasi autarky for large portions of the population. Mighty "petrol station" Russia, got fucked by their reliance on ICE. Solar and wind will work even in nuclear wastelands, and replacing that solar panel is still cheaper than the cheap drone, which damaged it.
Tl;dr: You can restructure military doctrine and defense focus to make bunkers an easy sell to your citizens. In fact, going any other way should raise questions about aggressive ambitions.
If art is shaped by popular demand only, you will get nothing but the most comfortable, unchallenging, forgettable popculture fluff imaginable.
Then again, the US learned nothing from Ukraine and still attacked Iran - the Shahed country. Hopefully, China is a bit more considerate about Taiwan.
In the concrete instance of AA defense you are correct. You basically can't prevent drone damage actively, since every AA system can be easily overwhelmed and costs are very asymmetrical. However, the damage taken does not change much, strategically. Highways, rail tracks and the ports are quickly operational again. That's my point. See war in Ukraine. Nearly every refinery in Russia has been hit by drones. Complex structures, yet most of them are operational and sustained income damage is comparatively low. Of course that's expensive for Russia, but most of that economic damage is offloaded to the future. Same the other way around. Russia is successfully bombing Ukraine every day, yet the front line has hardly changed in years.
Also, the immediate AA defense perspective is a momentary picture. In the future we will see more underground/protected infrastructure immune to drones, as well as more symmetrical defense options (cheap drone on drone systems, lasers, ...). Cheap drones will not become bunker busters any time soon. Doctrines will also likely adapt more rapid initial escalation since nobody wants the prolonged attritional warfare expected with cheap drones.
Overloading the military with civilian functions aids fascistoid developments. The military should serve defense, not power projection. Making it a welfare institution makes warfare a way of life. Relevant documentary: https://www.imdb.com/title/tt0120201/
I think the problem is, apart from deploying nuclear weapons, air-based warfare campaigns have never really been all that effective at achieving strategic goals. Bombing stuff always seems promising, but in reality consequences are hard to predict due to complexity and results tend to be underwhelming.
For the same reason, cheap drones favor the defender IMO. A typical country can sustain quite a bit of damage on home soil, without losing will to fight and popular support. On the other hand, the attacking carrier on their coast line, becomes a singular target instrumental to the aggressor's war efforts. On the front, cheap drones freeze the contact line, which of course also benefits the defender.
Ukraine is very successful at keeping front lines relatively stable, despite man power shortages, due to drones, but neither Ukraine, nor Russia are very successful with their deep strike drone campaigns. I mean stuff is burning all over, but it changes little for ending the war so far. Train tracks are quickly back in operation, refineries repaired, stocks replenished, behavior patterns changed. Population experiencing reverse hedonistic adaptation to the new shitty normal. No models to predict resilience. Collapse may happen instantly or not at all.
Also pretty evident with the US/Israel aggression against Iran right now. It somehow always takes a lot more than expected to break your enemy in the deep.
In Germany it's been like that: You objected military service, you had to do mandatory civilian service, e.g. aiding disabled people, for 9 months . I would prefer there to be a choice right from the beginning. So while mandatory to spend a certain amount of your life time for the collective, some agency remains.
Israel is bad example, because there objection is notoriously hard, yet more relevant than ever.