I use Migadu to host my email, and they have a really cool wildcard-style system where I can basically define a regex string, and any email address matching that string goes to my main email.
In my case, I use a specific set of numbers just before the @ as the matching string (let’s say, “45”), so email to firstname45@domain works, or doctor45@domain, or library45@domain all get delivered. Since the spammers don’t know this, I don’t get any spam. But I still have the benefit of being able to make up arbitrary emails on the spot for any purpose.