I currently work at project44 and it's really nice here!
60 karma · joined January 14, 2019
At the end of the day, I recommend figuring out your preferred distro if you haven't already and going from there. Most major distributions like Ubuntu, openSuSE, and Fedora have Raspberry Pi versions.
If you're asking for optimizations, you'll find them in keeping as few processes running as possible, and you may get better speeds by hardware means such as purchasing a micro SD card with faster read-write capability or getting a cooling fan for the CPU.
Hope that helps, and props to making and running your own website from home! :)