I switched to Dvorak before I started uni. I have been typing dvorak the majority of my typing.
Still discovered the hard way that I needed an ergonomic keyboard. I use a kinesis advantage, but frankly a Microsoft one will do. It just needs to be enough.
Also major factor: Switching away from a mouse. Every time I've done full time work at a computer (i.e. when I'm not studying), I got wrist pain.
Switching to a touchpad is tiring for the fingertip, since it's not designed to drag on a surface all day.
But switching to a trackball has been a fantastic choice (six or seven years ago by now - some kind of red Kensington ball). I think there's so much more choice in using a trackball than a mouse or a touchpad, since it can be operated with the fingertip or the hand, and it's trivial to operate it without bending the wrist badly.
I got the ergonomic keyboard before the trackball; but the trackball made an almost instantaneous difference, whereas the keyboard only makes a cumulative difference - nowadays I can use a straight keyboard temporarily (e.g. if I want to go somewhere and use a laptop, I can, even for weeks at a time) but I wouldn't want it fulltime.