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g10ron Ginkgo Bioworks (YC S14) is going public today

yep! have def had one drop after conversion.

g10ron Ginkgo Bioworks (YC S14) is going public today

It's not bad per se, it's just how it works. Like pretty much everything in life the outcome is dependent on the people involved. You're not getting the potential for more upside without the introduction of more risk.

Chamath is currently leading four biotech SPACS: DNAA, DNAB, DNAC and DNAD, each with a stated target, neurology, oncology, organs & immunology. Anyone looking to invest in the SPAC today should consider the likelihood of this happening, the potential targets, and the sponsors history.

Or you can wait for an announcement around a proposed merger, even up to the day the official stock starts being traded.

Again, just depends on risk tolerance. It's nice to least have the option to take part in these deals.

g10ron Ginkgo Bioworks (YC S14) is going public today

Probably not...I just came across it as part of my diligence before investing. Originally found on Twitter.

g10ron Ginkgo Bioworks (YC S14) is going public today

Was nice to have the ability to buy into SRNG early. This is more or less restricted to most through a traditional IPO.

g10ron Ginkgo Bioworks (YC S14) is going public today

Here's one of their more recent decks if anyone is interested: https://www.ginkgobioworks.com/wp-content/uploads/2021/08/20...

g10ron Building AI Trading Systems

Agreed. Many smaller, yet successful Hedge Funds limit the capital they manage for this very reason. Some strategies just don't work at certain scale.

g10ron Ask HN: Engineering group to fight Covid-19 needs fee waiver from Slack

Did they adjust based on this HN post? We are wanting to get the My Climate Journey Slack account (550+ people) upgraded as well...

g10ron SEC proposes changes to “accredited investor” definition

For the most part, the government shouldn't get to tell people what they can or can not do with their money. We don't currently stop people from going to vegas, buying lotto tickets, buying expensive cars, clothes, buying education, etc.

Said another way, 'anyone' can invest 'any' amount in a public stock today and lose it all tomorrow. Heck people were even suckered into mortgages they couldn't afford by our trusty banks.

g10ron Tesla to raise prices and keep more stores open

Tesla occupancy doesn't mean much for most of these malls/shopping centers, to be honest.

Apple/Nike/Target, sure. Tesla, no.

g10ron Tesla to raise prices and keep more stores open

Surely they understood this before the initial decision was announced. No way those leases were disappearing.

g10ron Ask HN: What company environment has enabled your best work?

Funny enough I've been obsessing over this concept of "aligning vectors" / measuring the impact of personal KPIs against the total progress of a business.

“Every person in your company is a vector. Your progress is determined by the sum of all vectors.” — Elon Musk

g10ron Gum disease–causing bacteria could spur Alzheimer’s

Certainly important for people to understand/be aware of the process someone such as Robert Moir (one scientist mentioned in the article) must navigate

https://www.statnews.com/2018/10/29/alzheimers-research-outs...

g10ron Gum disease–causing bacteria could spur Alzheimer’s

Awesome thank you.

g10ron Brain researchers warn that lack of sleep is a public health crisis

Sleep is fascinating to study. So much to discover.

Awesome book: Why We Sleep by Matthew Walker

g10ron Ask HN: How to pitch startup to corporates without losing ownership?

The best protection is going to be execution.

NDAs aren't really going to help you in this regard.

Just take some meetings, tell them what you're working on and if some form of collaboration is of interest.

g10ron Ask HN: Does ML research ever get translated to industry?

What are you working on?

g10ron Ask HN: Advice on acquiring clients for private beta?

Approaching as a "partnership" may be useful. You can always increase pricing after your initial customers.

Also, be careful thinking you have a solid MVP.

g10ron Ask HN: How to found a company as a single founder?

arbitrary number + that's what, a couple months? That's nothing.

g10ron Ask HN: How to found a company as a single founder?

options: 1. start over and don't work with the current cofounder. 2. keep going with current product, structure co-founders financial contribution as an investment (use a SAFE or something) and remove the person from day to day operations in the company.

g10ron Amazon Starts Selling Software to Mine Patient Health Records

https://www.newyorker.com/magazine/2018/11/12/why-doctors-ha...

g10ron AI Playbook

There's a long-standing relationship there.

g10ron AI Playbook

Well, one reason to "keep up with trends" is because if your direct competitor does use ML to unveil some market/product/business opportunity or optimization, and you (executive/CIO/CEO) weren't at the least looking into the technology, heads are going to roll.

g10ron AI Playbook

Yes, similar to what CAA did for the entertainment agency world. You may find it interesting to read, Who is Michael Ovitz?

g10ron Facebook is taking on Tinder with new dating features

Soon people will receive the following message from FB: “Hey, meet/date/marry this person. Trust us, you are perfect for each other." :)

g10ron Poor Grades Tied to Class Times That Don’t Match Our Biological Clocks

100%

g10ron Snap is laying off about 100 engineers

Reducing engineering capacity does not necessarily mean reducing the pace of a companies innovation.

g10ron The Business of SaaS

Connections certainly help but aren't required. You need grit and a solution (or an idea of a solution) that's solving a pain point worth paying to alleviate. Ideally 10x better and cheaper than what's currently in the market. At first, you will be the salesperson and you have to realize that comes with a lot of rejection.

g10ron What makes truly great leaders, the compression of seed and the future of YC

- conviction around ideas that are right, but not consensus. Rebel thinking.

- update your mental model with data.

- conversations around what's working, not working.

- one thing about a founder to decide to invest: shadow a founder for a day. Real life better demonstrates true nature of people vs meetings/stories/emails/interviews.

- always think about what can go wrong with your product, strategy, competitive landscape. Extreme alertness.

- if you have a good product, you can fix sales, customer success, marketing, etc. If you have a bad product, even doing everything else write doesn't help.

- Concerned about excess capital in seed markets. Bad companies shouldn't be raising money. Bad for the ecosystem as a whole.

g10ron Lessons I Wish I Had Learned Before Teaching Differential Equations (1997) [pdf]

why?

The question my three-year-old son asks over and over each day. It's exhausting, and I love it. I do my best to provide the answer instead of simply stating "because" or "just do it" as one of my greatest fears is to suppress his natural desire to understand as much as possible about the world. Also, as a child I hated memorization, yet loved delving into a subject that intrigued me.

g10ron Ask HN: How do you set prices?

https://www.saastr.com/a-little-less-about-pricing-a-little-...