Back in the day we mostly did it to cheat in Halo 2 online multiplayer.
I remember being 13 and would stick a butter knife into my Xbox DVD drive so the "old maps" (on the disc) would fail to load, forcing the game to load a "new map" on the hard drive which I patched via soft modding the console allowing FTP to edit the maps on the hard drive.
People don't realize PPIs are a short term solution. PPIs are terrible long term. That being said, I'd be long dead without them. They are truly a life saver until you find out the root cause. Many trips to the ER and years later, I found out avoiding gluten and taking probiotics cured mine.