715 karma · joined March 11, 2015
back of the envelope:
- each gamete has 1 of 2 choices for 23 chromosomes.
- you need to find any two non-overlapping
- probability of non-overlap is 0.5^23 for any pair
- number of pairs equals (n choose 2) where n is number of gametes = n!/ (2 * (n - 2)!) = 0.5 * n * (n-1) = 0.5 * (n^2 - n)
- to get a 50/50 chance of finding the right gametes: 0.5 = 0.5^23 * 0.5 * (n^2 - n), which is equivalent to: 0 = 0.5^23 * (n^2 -n) - 1
- solved via wolfram alpha, you would need to screen 2897 nuclei non-destructively to get a 50% chance of being able to generate a clone.
I'm not aware if this is possible or not. But obviously if you can just replace chromosomes in-nucleus that is easier than screening, but if you can do that you don't really need this whole process since you can just replace the nucleus after IVF. If you could harvest a sex cell and do meiosis in a test tube, that would also get you your nuclei right away as well -- from 10 seconds of googling, I don't think we have this yet.
I think when they screen zygotes they do it after some replication has happened, so the math really works against you if you need to combine sperm+egg pre-screen because you don't get the birthday paradox effect if you have to commit to your pairings beforehand, you'd need to huge egg supply as well.
To go any faster you'd need more tankers as well. I don't forsee the tanker having commercial value short-term, so this would still increase the cost. With two tankers though, you can just have a full tanker waiting in orbit which is the fastest possibility, so there is no need of extra boosters in that case.
I agree with the premise of multiple boosters though. I wonder if a spacecraft could be made that could do both commercial earth orbit satellite missions, and serve as a tanker. This could finance a larger number of tankers. I think you'd need a 3rd stage on top of the tanker in this case to get the satellite in position. [EDIT: I mean either carry the extra fuel, or carry a 3rd stage + satellite, not both at the same time.]
I believe Elon said it would take 40-100 years for the population to reach that point, and he is saying that there will be a return mechanism, and a probably an extreme labour shortage which favours a strong bargaining position for both the entrees and the Mars local population. Ideally I'd like to see the return ticket + life support until the next return flight provided as part of the entrance fee to minimise risk, but there is still the problem of enforcing the contract.
[EDIT: I don't consider this a "fair" argument so I left it out, but as an aside, if minimising pain is your goal then mass sterilisation is the optimal strategy IMO -- there is no reason to continue the human race which will certainly produce millions of people in pain -- and if you have another goal which requires human existence to fulfil, then decreasing our extinction probability should be a huge priority]
And I also think if colonisation ever was big enough to absorb a significant (i.e. 5%+) portion of Earth gross product (i.e. the sum of GDPs) then it could also improve life on Earth by improving the effective ROI of the capital deployed elsewhere.
Designing for automation, however, involves significant service-model constraints. For example, some of the large services today depend upon database systems with asynchronous replication to a secondary, back-up server. Failing over to the secondary after the primary isn't able to service requests loses some customer data due to replicating asynchronously. However, not failing over to the secondary leads to service downtime for those users whose data is stored on the failed database server. Automating the decision to fail over is hard in this case since its dependent upon human judgment and accurately estimating the amount of data loss compared to the likely length of the down time. A system designed for automation pays the latency and throughput cost of synchronous replication. And, having done that, failover becomes a simple decision: if the primary is down, route requests to the secondary. This approach is much more amenable to automation and is considerably less error prone.
JWZ has some referrer detection so you might want to open it in a private tab to get around.
Hacker News has a moderation policy and mod team that gives the discussion some very desirable characteristics:
- a sort of professional level of conversation is maintained. Roughly equivalent to a casual conversation with a co-worker, over lunch, is sort of the overall tone.
- general rejection of memes and shitposting as being against the purpose of the site -- the point is real discussion an exchange of information, not low effort karma generation
- Paul Graham's essay about different levels of disagreement: generally people attempt to discuss the core ideas of the posts and not just hammer away to trivilaties
Most of the programming related subreddits don't have anything like the overall tone, cohesiveness, or moderator activity/discipline of Hacker News. There are some subreddits that I would say are as good as Hacker News for discussions about their chosen topic, for example, http://reddit.com/r/spacex . But the overall programming subreddits are not equal to this.
The short sellers are anyone with a negative outlook on the stock. For example, some hedge funds do 50% buying, 50% short selling, so in theory they are neutral to overall market conditions.
The brokers in this case have been permitted to lend out the stock to earn extra money, the short sellers are ordinary customers of the brokers, the short sellers don't necessarily have any special relationship with the brokers.
The market maker would be buying as much as selling, and not holding any position over extended time, so they don't influence this event.
In theory, the short sellers have to pay up to meet their obligations.
If Google negotiates the border location with the governments, according to the governments political needs, that is Google's choice -- Google can do this to try to maximally satisfy the governments. This is politically complicated.
If Google wants to maximally satisfy the practical needs of the people who are actually going to the locations on the map -- all they need to do is identify the sovereign power. Exerting control is politically complicated, but this is not what Google needs to do, Google only needs to identify.
China (PRC) says that Taiwan is a province of China, but they don't control it. If you show up at the Taipei airport with a entry visa from the PRC, you will find that out.
A similar but more extreme example, Google Maps says Raqqa is part of Syria, but due to the war that isn't exactly accurate at the moment.
Determining which organization rightfully owns which territory is political.
Determining which organization actually controls which territory isn't political though maybe not any easier.
If Google's responsibility is to accurately represent the situation on the ground to their users, then it may not be easy but it isn't all that political.
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[PDF] http://minerals.usgs.gov/minerals/pubs/commodity/platinum/my...
On page 4, it says 2014 global consumption of Ir was 6100kg. (3rd last para).
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https://en.wikipedia.org/wiki/Iridium
Wikipedia article para 2 says global consumption and production is three tonnes.
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http://www.bloomberg.com/news/articles/2014-02-19/iridium-cl...
This (2014) article estimates global production as 129,000 ounces to 322,000 ounces, which is about 3500 kg to 9000 kg.
Edit: (tongue in cheek) maybe you can find something more in line with your expectations here: https://www.google.ca/search?tbm=isch&q=physics+comic+strips
There are more sophisticated schemes that allow you to check the amount in your account, and verify that your account was included in the total, without seeing the size of other accounts: https://iwilcox.me.uk/2014/proving-bitcoin-reserves .
Here is a report which uses the guideline to assess a company's posture after a hack: https://www.scribd.com/doc/309591980/ShapeShift-Postmortem (sorry about the scribd link, haven't been able to find pdf.)
Here is a narrative description of the hack that the above report is about: http://moneyandstate.com/looting-of-the-fox/