https://podcastindex.org/ is a great.
1,370 karma · joined September 1, 2015
> Automate Software Build and Testing Drone is a self-service Continuous Integration platform for busy development teams.
In this example, wouldn't it have cost this person $50 million dollars though?
Thanks for this. It's exactly the the format and depth I wanted.
I haven't been able to muster the time or energy to start digging into the quagmire that is the Python ecosystem but this seems like the perfect place to start (and hopefully stay for a while.)
Wow. I never considered such thing ever existed, but of course it did...
Maybe they're referring to using a prominent website as a C&C server? Wait... no, they've seen that before when they reported, in 2017, on a:
> "backdoor Trojan used comments posted to Britney Spears's official Instagram account to locate the control server that sends instructions and offloads stolen data to and from infected computers." [0]
So they must be talking about the novel use of an image in the staged delivery? Oh... nevermind, that can't be it either because their reporting on VPNFilter in 2018 mentioned:
> "stage 1 relies on a sophisticated mechanism to locate servers where stage 2 and stage 3 payloads were available. The primary method involved downloading images stored on Photobucket.com and extracting an IP address from six integer values used for GPS latitude and longitude stored in the EXIF field of the image." [1]
So yeah, I guess Ars hasn't seen Base64 before it was embedded on their site.
[0] https://arstechnica.com/information-technology/2017/06/russi...
[1] https://arstechnica.com/information-technology/2018/06/vpnfi...
No. That's part of why they're test is so expensive and their financials are so lackluster. They are apparently using a customized version of the lllumina's Global Screening Array according to their website and several other sources that show up in search results. That's a legit research quality genotyping platform from a world leading laboratory in the genetics space. This post from 2020 has a decent high level overview about it in the context of 23&me [0] though it might be slightly outdated by now and I've never heard of the company (xcode?) that wrote it (nor did I bother to look at what their product is.)
> If I was trying to launch a consumer DNA geneology service, I'd want to get network effects, so I'd want a test that was very easily affordable.
That's a pretty neive perspective. It ignores the value propositions of 23&me's product, economies of scale in the direct to consumer genetic testing space which were in large part enabled by 23&me's success, and all of the thorny bits related to questions about accuracy when presenting results. Not to mention that 23&me certainly capitalized on the network effect (which is being criticized a fair amount in this thread.)
> Who says their records are thorough enough to be valuable to drug companies?
GSK. See my other comment in this thread [1]
[0] https://www.xcode.life/23andme/23andme-v5-chip-dna-raw-data-...
That is a pretty awful click-bait title. Presumably the "$0" is in reference to their sub $1 share price?
The fact that they put everything behind a paywall _and_ slap on click-bait titles is confusing to me. I can't imagine paying for access to that type of writing.
In 2018 GSK made a $300M equity investment in 23andMe as part of a 4 year collaboration (with the option to extend for a fifth year) under which GSK had exclusive access to their data for use in drug target discovery programs, but [0]:
> All activities within the collaboration will initially be co-funded (50%/50%), with either company having certain rights to reduce its funding share for any collaboration programme.
So it seems they not only lost out on 5 years of developing their B2B business, but committed to covering a portion of the R&D costs over that period as well. There were terms about profit sharing on new developments, so it was a bet.
It doesn't sound like it worked out quite as well as either sided hoped though because in October 2023 (after the 5 year agreement) they entered into another agreement but this time [1]:
> Under an amendment to their Collaboration Agreement, 23andMe will receive a $20 million upfront payment for a one year, non-exclusive data license. > [...] > for a 12-month period, and [23andMe will] offer its research services for analyses of the data over that same period. Any new drug discovery programs that GSK chooses to initiate during the agreement will be owned and advanced solely by GSK.
[0]: https://www.gsk.com/en-gb/media/press-releases/gsk-and-23and...
[1]: https://investors.23andme.com/news-releases/news-release-det...
For example, comments on Britney Spears' Instagram page: https://arstechnica.com/information-technology/2017/06/russi...
Vindeloo is derived from Portuguese cuisine as well. In fact, the Portuguese are widely accredited with introducing spicy chili peppers into Indian cuisine.
> This preset will become the default preset in a future release of starship
It also links to an open issue on the GH repo about it [1] (although that issue is 2 years old and doesn't seem to be top priority.)
The argument can certainly be made though. At least regarding their consumer laptop decision circa 2015 when, in addition to the quality issues, they were shipping the Superfish ad-ware which was installing a notably insecure self-signed root certificate to deliberately Man-in-the-Middle HTTPS connections so it could inject display ads. See:
- https://marcrogers.org/2015/02/19/lenovo-installs-adware-on-...
- https://blog.erratasec.com/2015/02/extracting-superfish-cert...
Would it?
* What's the future of Servo? (578 points) Aug 14, 2020 https://news.ycombinator.com/item?id=24156504
* Servo Engine contributions this year (238 points) July 1, 2021 https://news.ycombinator.com/item?id=27700836
* Can Servo be a clean and modern reference platform for developers? (62 points) Aug 27, 2015 https://news.ycombinator.com/item?id=10129518
Source code for the backend here: https://github.com/drolbr/Overpass-API
Found from this link listed in the help modal: https://overpass-api.de/ (also links to two additional frontends.)
I thought I remembered more comments on that thread, but I guess nothing more than what's there needs to be said.
Is it too prying to ask what that means in terms of your outcome? Idk what the WARN act is, and I understand that my question may be neive or too personal to post an answer to publicly, but I'm curious what the alternative to signing is/was and if the answer is generally applicable or specific to the company/agreement.
The Guild [0] does some exceptional work in the GQL world and specifically server side with Yoga, Envelope, Hive, and some other stuff; but it does tend to be JS focused for now.
I couldn't disagree with this more. Reinventing something in public view can be extraordinarily valuable, even if without a clearly defined problem to address. Off the top of my head:
- Learning in public can have benefits: I personally tend to write much better software if I know there is any chance someone else might see it and reinventing the wheel (Todo app anyone?) is a great way to focus on learning some new techniques or technology without the added overhead of also inventing a novel solution to some hard problem.
- Contributing to the dominate project in any space requires working within the constraints of the existing code and project/user expectations, and if you just show up out of the blue trying to "apply lessons learned", you also need to make a convincing argument for why your way is the better way. On the other hand, reinventing the project allows the freedom to experiment and demonstrate some radical alternative and doing it in public allows anyone (including dominant project maintainers and users) to learn from it.
- People that don't have any interest in the original project, but do have interest in aspects of the reinvention can benefit. For example, I haven't used Calibre in years and don't plan to now, but I'm grateful the author shared this because I hadn't heard of Tauri prior or seen a Bun project, and now I'm exploring the repo and learning something new.
> There are many good open source projects that could be great if more developers would work on them.
Eh. Sounds like a Zero-Sum Fallacy.
Don't be sad! Based on the most recent threads discussing Calibre [0] it would seem that the disclaimer isn't strictly necessary, and actually OP appears to be addressing a problem that resonates with a fair number of people on HN!
That said, there is always going to be someone that will "have a few qualms with this app" [1] regardless so it doesn't hurt to get in front of the question.
[0] See:
- Calibre New in Calibre 7.0 -- https://news.ycombinator.com/item?id=38316846
- Calibre replacement considerations -- https://news.ycombinator.com/item?id=37364885
A turn off from what, exactly? IMO it does a great job of quickly setting the context of what you are looking at before describing why you might care:
> It's not production ready at all, but that doesn't mean there is no value in the project. If you ever wanted to read database code without getting overwhelmed by massive amounts of code, dbeel is for you.
Please do!
Indeed! In fact, someone mentioned this article in the thread about the Python JIT from a few days ago: