ck_one

Capital gains tax is clearly lower than income tax. So why did you change your mind?

Does that mean zebra fish with their ability to regrow the retina get cancer at a higher rate?

Most patients get tinnitus after hearing degradation. So my first advice is to do a hearing test. You mentioned you visited a doctor, was your hearing normal?

Tinnitus is still in the early stages of research. But the notion of just accept it, it can't be fixed will not be true forever. Researchers just recently started to cure some form of genetic hearing loss. That means one part of the puzzle of transporting gen editing viruses to the inner ear is solved. Next up is figuring out what gen edits are necessary. The field gets surprisingly little funding even though we have an aging population and lots of veterans with hearing issues. Many labs have tiny budgets <1 Mio per year but are making good progress every year. My guess is when one of the rich founders gets it (Elon, Sam, Larry, Brin etc) and decided to do something about it we will see real progress.

More and more SaaS companies like ServiceNow or Hubspot are creating new tollgates for agent api calls. How do you think will this impact Airbyte Agents? I guess that replicating data locally will be harder since the platforms will try to protect it or charge for it.

What self-built capabilities do you like the most that claude code doesn't offer?

Wild how quickly developer workflows change. I went from cursor -> claude code CLI -> emdash (mix of claude code and codex now)

Didn't see it, thanks!

Do you plan on Open Sourcing it? A bit scary to just execute a random binary and put in a bunch of API keys.

How do you think big labs will try to attack you guys? Why not just close the data to them?

It didn't use web search. But for sure it has some internal knowledge already. It's not a perfect needle in the hay stack problem but gemini flash was much worse when I tested it last time.

Do you remember how to get around those tricks?

When I tried it without web search so only internal knowledge it missed ~15 spells.

If you just ask it you don't get the same result. Around 13 spells were missing when I just prompted Opus 4.6 without the books as context.

Then it's fair that id didn't find it

Just tested the new Opus 4.6 (1M context) on a fun needle-in-a-haystack challenge: finding every spell in all Harry Potter books.

All 7 books come to ~1.75M tokens, so they don't quite fit yet. (At this rate of progress, mid-April should do it ) For now you can fit the first 4 books (~733K tokens).

Results: Opus 4.6 found 49 out of 50 officially documented spells across those 4 books. The only miss was "Slugulus Eructo" (a vomiting spell).

Freaking impressive!

This is the moment for Europe to show that you can do gov and business differently. If they get their s** together and actually present a viable alternative.

Is that actually possible? Can we do a live test here?

Let's say we want this dataset: Credit card line items for 35-year-old dentists living on the 400 block of Elm street in local town

How much do I have to pay you to get it?

In many fields there is no moat. It’s an execution battle and it comes down to question: can the startup innovate faster and get to the customers or can the incumbent defend its existing distribution well enough.

Microsoft owns GitHub and VSCode yet cursor was able to out execute them. Legora is moving very quickly in the legal space. Not clear yet who will win.

It's better than perplexity on certain tasks! Pretty impressive!

Feedback: the mermaid charts are a bit annoying when they are not needed

Our of curiosity, what web index do you guys use right now and does it make sense to build your own index at some point?

What object detection model do you use?

Quetzal as a product is inevitable. It will make it even easier to target international markets from day one with a tiny team. Congrats on the launch! You rock! Greetings from section 4D!

What's your next step? Why did you decide to focus on enzyme design?

Can anyone recommend a method to deduplicate pdfs? The hash is often different but the content and meta data is 99.99% the same.

There is also active development for tinnitus/noise induced hearing loss. Dr Chen from Harvard is working on it. He was also involved in the research linked in the article. They are getting closer to a cure. Here is an interview with him: https://www.youtube.com/watch?v=lJr86MUYJ8M

Pretty cool what they are working on. However, I wished there would be more funding for restoring hair cells which are the root cause for most people with hearing loss.

Researchers are getting closer. Dr. Chen from Harvard was able to regenerate hair cells in mature mice last year.

The problem is also becoming more widespread. 30 Mio people in the US and 400 Mio people worldwide have disabling hearing loss. Regenerating hair cells and the synapses around them would also cure Tinnitus. 30 Mio x $5k for a treatment = $60B market (probably way bigger with aging population)

I think we probably need more rich tech billionaires to get affected to attract large funding.

What billionaires that you know are affected besides:

- Brad Jacobs

- Ryan from Flexport/Founders Fund

Can you share some insights on what the issues were?

Would avoid the eastern part though

Just spend some time in SF. There are so many people working/playing with AI. Also not too hard to bump into people who do top notch research at a lab.

Is this an acquisition or an acquihire?

Why don't you also use GPT4-V for that part?