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chromatin

1,461 karma · joined December 29, 2019

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chromatin··on Demand for human radiologists is at an all-time high
I am a natural skeptic, but in this case I think it is just an accident of history how different systems developed.

FWIW, although this is not well known, many medical schools offer combined BA/MD degrees, ranging from 4-8 years:

https://students-residents.aamc.org/medical-school-admission...

When I went 20 years ago, my school did not require a bachelor's degree and would admit exceptional students after 2 years of undergraduate coursework. However I think this has now gone away everywhere due to AAMC criteria

chromatin··on Demand for human radiologists is at an all-time high
Partially true, and the answer to that is runway -- it will be a very long time before all the other specialties are fully augmented. With respect to "non-surgical" you may be underestimating the number and variety of procedures performed by non-surgeons (e.g. Internal Medicine physicians) -- thyroid biopsy, bronchoscopy, endoscopic retrograde cholangiopancreatography, liquid nitrogen ablation of skin lesion, bone marrow aspiration, etc.

The other answer is that AI will not hold your hand in the ICU, or share with you how their mother felt when on the same chemo regimen that you are prescribing.

chromatin··on Demand for human radiologists is at an all-time high
The belief is -- and it is one that I share -- that this makes for more well rounded, human physicians.

Additionally, a greater depth of thinking leads to better diagnosticians, and physician-scientists as well (IMO).

Now, all of this is predicated on the traditional model of the University education, not the glorified jobs training program that it has slowly become.

chromatin··on Zip Code Map of the United States
My ZIP code happens to be shared by two separate cities and there are a few websites (Github, I'm looking at you) that will fail the payment, registration, etc. attempt if you don't enter the municipality that it THINKS is correct.
chromatin··on Open models by OpenAI
I think his point is that slavery is not outlawed by the 13th amendment as most people assume (even the Google AI summary reads: "The 13th Amendment to the United States Constitution, ratified in 1865, officially abolished slavery and involuntary servitude in the United States.").

However, if you actually read it, the 13th amendment makes an explicit allowance for slavery (i.e. expressly allows it):

"Neither slavery nor involuntary servitude, *except as a punishment for crime whereof the party shall have been duly convicted*" (emphasis mine obviously since Markdown didn't exist in 1865)

chromatin··on Perplexity is using stealth, undeclared crawlers to evade no-crawl directives
402 Payment Required

https://developer.mozilla.org/en-US/docs/Web/HTTP/Reference/...

Sadly development along these lines has not progressed. Yes, Google Cloud and other services may return it and require some manual human intervention, but I'd love to see _automatic payment negotiation_.

I'm hopeful that instant-settlement options like Bitcoin Lightning payments could progress us past this.

https://docs.lightning.engineering/the-lightning-network/l40...

https://hackernoon.com/the-resurgence-of-http-402-in-the-age...

chromatin··on Writing a good design document
The author makes the following assertion:

    Let me illustrate a common code organization issue some programmers run into on their first day. The novice writes

    terminal.print("Hello world")

    Then they decide they want to make the text red, so they edit their program to

    
    terminal.print("Hello world")

    terminal.setPrintColor("red")
        
    And then they're confused that it didn't come out red. They haven't internalized that the first line of code happens before the second. They just get a soup of code on the screen that kind of has the ingredients for a program, and expect the computer to do what they want.

I find this _extremely_ surprising???
chromatin··on USB-C for Lightning iPhones
I actually want lightning for my USB-C phone :/
chromatin··on Show HN: Compass CNC – Open-source handheld CNC router
Could be interesting, but I didn't see any /PICTURES OR VIDEOS/ of what I could create with this product.
chromatin··on Learn OCaml
Do these exercises go with a book?

The only (obvious) option is to begin solving problems.

If someone does not already _know_ OCaml, I fail to see how this is a way to learn.

A better title might be "Practice OCaml"

chromatin··on Bot or human? Creating an invisible Turing test for the internet
"When a measure becomes a target, it ceases to be a good measure".

https://en.wikipedia.org/wiki/Goodhart%27s_law

BRB, changing the simulated latency in my bot.

chromatin··on How much information is in DNA?
The article massively undersells the information content of the genome in several key ways. A non-comprehensive list of these (before my morning coffee forgive me) includes:

- DNA methylation (https://en.wikipedia.org/wiki/DNA_methylation)

- Interactions of alleles (what article refers to as the "two versions of each base pair")

- Duplications, deletions, inversions, and other structural variations (https://www.genome.gov/genetics-glossary/Structural-Variatio...)

- Physical proximity interactions in 3-dimensional space (https://cmbl.biomedcentral.com/articles/10.1186/s11658-023-0...)

- Combinatorial effect (massive) of different alleles in complex systems

Overall, it's not sensible to compare a linear sequence of bits, like a CD (sibling comment) or DVD (the article), to the linear sequence of the genome and conclude that their information content, based on length alone, is in any way comparable.

chromatin··on How much information is in DNA?
> There's less than 80 minutes worth of music's worth of information in our genomes

What an insanely bad take.

Not only did you not read and/or comprehend the article, the article itself undersells the information content of the genome (I'll post on this at the top level).

> You are not predisposed to be anything.

This does not logically follow your preceding statement, even if we were to accept the foregoing limited information content as factual

chromatin··on HDR‑Infused Emoji
Looks incredible (Firefox)
chromatin··on Why I don't discuss politics with friends
Yes, that also struck me as nonsensical.

If he were really trying to demonstrate a 2d Gaussian, it would instead be a circle or elipse of points with highest density at the origin.

perhaps in the end he was not

chromatin··on Xee: A Modern XPath and XSLT Engine in Rust
NCBI still emits XML from their most prominent databases (e.g., PubMed). I'm looking forward to adopting this library into some of my production code that interfaces with PubMed!
chromatin··on Woman who had pioneering cancer treatment 18 years ago still in remission
"Cancer protein"s are rarely restricted to the neoplastic clone
chromatin··on Ross Ulbricht granted a full pardon
> Nothing about Donald Trump is Libertarian.

so what? Coalition-building is common in the rest of the democratic world. This is, in my view, a similar thing.

chromatin··on Ross Ulbricht granted a full pardon
> Preëmptive

amazing use of the diaresis

Regarding the substance of your comment, we do not have (IIRC) established judicial precedent for the constitutionality of preëmptive pardons. The practice originated with Ford pardoning Nixon, and has not yet been challened nor withstood judicial examination.

Personally, I'd like to see some of Biden's pardons challenged.

> (3) Issued after the presidential election in the final year of their term.

This is an interesting one for those who are seeking a second term but are at risk of losing

chromatin··on Show HN: Pica – Rust-based agentic AI infrastructure (open-source)
Back button is nonfunctional (because of the redirect to /home)
chromatin··on Mixxx: GPL DJ Software
How about a USB knob?

https://binepad.com/products/bnr1-v2

chromatin··on Mixxx: GPL DJ Software
That stinks. I know professional DJs often have a backup music player for this very reason. Even hardware can fault.
chromatin··on Dioxus 0.6 – Crossplatform apps with Rust
I also use leptos, which appears to have a lively, developing ecosystem.

The contrast is interesting because leptos was the brainchild of an individual (Anglican priest, too, IIUC) whereas Dioxus is venture-backed.

chromatin··on Show HN: Search and Analyze SEC Filings of Publicly Traded Companies with AI
Looks fantastic. I was thinking about doing something in a separate industry.

Was this done by a solo developer? How long did it take, and had you ever done a RAG-type application before?

chromatin··on 20 years of Google Scholar
21. No API
chromatin··on Ritonavir Form III: A Coincidental Concurrent Discovery
I believe you're thinking of ritonovir, which is exactly the story in the linked article.
chromatin··on USGS uses machine learning to show large lithium potential in Arkansas
Serious question:

Given the mood alerting properties of lithium, are people living here chiller than would be expected (controlling for instance for poverty / SES) ?

chromatin··on Boeing to Sell at Least $10B in Shares to Plug Cash Drain
Came here to ask the same question.

My intuition is yes -- Boeing is America's last / only major commercial aviation jet mfr. -- and I don't think Uncle Sam will let them fail. Economically, I disagree with such a policy, but there's no reason I shouldn't profit from it.

chromatin··on Is AWS S3 having an outage?
Cloudfront is: my small, not even yet profitable SaaS landing page and javascript frontend, served by CloudFront, are down since about 17 minutes ago (3:28 US Eastern)

the API whcih sits behind ELB is working fine

edit: us-east-2

chromatin··on US man, 81, sentenced to six months for creating giant hybrid sheep for hunting
Shouldn't be a crime IMO. Hope he wins on appeal.
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