HNHacker News
TopNewBestAskShowJobs

cariaso

269 karma · joined February 13, 2011

https://patientuser.com

I created and used to maintain https://snpedia.com and https://promethease.com

[ my public key: https://keybase.io/cariaso; my proof: https://keybase.io/cariaso/sigs/0a6RQiNu9TEmb_fZFIytJnMKuLYWgq4OHK1B3il_S5g ]

submissionscomments
cariaso··on How to sequence your DNA for <$2k
https://patientuser.com
cariaso··on How Potatoes Evolved
I can easily forgive the statement you highlighted, but there is zero information about potatoes in this one:

Along with wheat, maize and rice, they are estimated to account for up to 80% of all calories eaten by people worldwide.

cariaso··on Bioinformatics CLI like agrep running on GPU in the language mojo
https://bsky.app/profile/binomicalabs.org/post/3lrsj6bcmus2v
cariaso··on Big banks explore venturing into crypto world together with joint stablecoin
If the GENIUS Act becomes the law, we're in for a FUBAR situation when a stablecoin issuer ends up insolvent. Even more concerning, if a bank custodian for a stablecoin issuer's reserves ends up insolvent, the claims of the stablecoin investors will come ahead of the bank depositors. That's right. Crypto comes ahead of ma-and-pa.

https://www.creditslips.org/creditslips/2025/05/the-genius-a...

cariaso··on Introducing command And commandfor In HTML
everyone is crediting intercal but

https://en.wikipedia.org/wiki/Comefrom

speaks to the history and rightly credits larry clark

cariaso··on Software developer arrested in connection with murder of healthcare executive
Nit

https://github.com/lnmangione

...."Active" GitHub?

cariaso··on An Update on Apple M1/M2 GPU Drivers
Alyssa Rosenzweig
cariaso··on U.S. imposes first-ever national drinking water limits on PFAS
https://gosimplelab.com/ZM7S1O is my report. I found their UI/UX quite good, and very comparable to a 23andMe experience. Pleasantly surprised to say there were zero attempts at ongoing subscription upsells, reengagement, virality etc.

Since my collection was based on a plastic bottle, I doubt microplastics would be part of the report. However the same lab offers other tests with different collection containers and different assays.

https://mytapscore.com/pages/specialized https://mytapscore.com/products/pfas-water-test https://mytapscore.com/products/microplastics-water-test

since the back end testing and reporting is done through gosimplelab you might wish to look at their offerings more directly https://gosimplelab.com/solutions/pfas

cariaso··on U.S. imposes first-ever national drinking water limits on PFAS
https://mytapscore.com/

I've used them and been happy with the report. Happy to share if requested.

cariaso··on Autonomous trucking is harder than autonomous rideshare
my point was not about the existence of a bread ration it was about the drive for ever bigger boats to haul ever more capacity.
cariaso··on Autonomous trucking is harder than autonomous rideshare
sure here’s one.

https://en.m.wikipedia.org/wiki/Isis_(ship)

As part of the

https://en.m.wikipedia.org/wiki/Cura_Annonae

cariaso··on The roots of ancient Rome's gladiator fights
I was under the impression that cowardice in battle was sufficient.
cariaso··on Does DNA have the equivalent of IF-statements, WHILE loops, or function calls?
https://berthub.eu/articles/posts/amazing-dna/
cariaso··on Electric eel’s zap can transfer genes to nearby animals
It's more than natural selection. https://en.wikipedia.org/wiki/Electroporation enables gene transfer.
cariaso··on Pig brain function under extracorporeal pulsatile circulatory control
3.5 million pigs are slaughtered for food each day.

2 pig subjects "were sedated with an intramuscular injection of tiletamine and zolazepam (4–8 mg/kg of each, in equal amount), atropine (0.04 mg/kg) and buprenorphine (0.05 mg/kg). They were then administered inhaled isoflurane, except during neurophysiological recording as noted below, and oxygen (2 L/min). These gases were applied first via snout mask and immediately afterwards via endotracheal intubation with mechanical ventilatory support. General anesthesia was maintained throughout the rest of the life of the animals, including euthanasia."

That protocol was approved by some suitable committee, in accordance with the Animal Welfare Act and similar protocols. I think most people informed of the details and the purpose of the research would agree the benefits easily justify the cost of their sacrifice.

cariaso··on Trucking startup Convoy closes operations with no buyer
https://www.epsilontheory.com/the-united-states-of-bed-bath-... gives more details
cariaso··on Show HN: PyTorch search engine
that seems like a super valuable domain being very under used.
cariaso··on Why do placebos work? Scientists identify key brain pathway
yes

https://www.snpedia.com/index.php/Rs4680

and the others mentioned at

https://www.snpedia.com/index.php/Placebo

cariaso··on On the Decline of Perl – external factors
I was a bioinformatician who worked on the Human Genome Project [ https://www.foo.be/docs/tpj/issues/vol1_2/tpj0102-0001.html ]. I used perl daily for years. In ~2004(?) I attended a San Francisco Perl Mongers User Group meeting where Randal Schwartz confirmed that Perl6 would sufficiently break backwards compatibility that the CPAN would be started from scratch. I walked out of that meeting and said out loud "oh well, I guess it's time to switch to python".

I firmly believe that it wasn't specifically about the switch to perl6, it was about the loss of the cpan that broke the camel's back.

cariaso··on How to Safely and Ethically Film Police Misconduct
worth noting that MN National Guard seems to have replied to this specific video and say that it' is not them.

https://twitter.com/MNNationalGuard/status/12670051854922260...

This doesn't quite disagree with your statement, but I'd like to ensure the correct officers are identified and disciplined.

cariaso··on Show HN: Just One Earth – Bite sized climate existentialism
“Unfortunately you had to stop the pollutive effects of 0 humans in the process, but their sacrifice is not in vain.“
cariaso··on Most U.S. Dairy Cows Are Descended From Just Two Bulls
Most of the statements there are reasonably well founded. The specifics of 'Turkey' may be a bit off, but broadly I'd agree with the comment you're replying to.

https://www.snpedia.com/index.php/Lactose_intolerance and https://en.wikipedia.org/wiki/Lactase_persistence

cariaso··on Her Various Symptoms Seemed Unrelated, Then One Doctor Put It All Together
> many more are not.

True, but

https://en.wikipedia.org/wiki/Sci-Hub

https://sci-hub.tw/

sad that it needs to exist, but good that it does.

cariaso··on Break free from traditional email - Host your own server
Could you share info about the arcane process with me ( cariaso@gmail.com ) . I manage delivery to most sites with no issue, but hotmail nearly always ends up in spam, and I'd love to try and address this.
cariaso··on Several departures at Kleiner Perkins
For the same reason Hemingway, Tolstoy and Faulkner write differently. The original text is only applicable when both are viewed positively. Your sentence applies when it's the less crappy of two options.
cariaso··on Problems with Object/Relational Mapping (2006)
I believe you are correct about the Khmer Rouge period being the source of the bulk of the Cambodian problem, however the museum's collection was quite comprehensive. It's been too long since I visited (and it seems they have since been forced to relocate) for me to be certain of what if any of the collection covers US secret war period, but I'm certain that I saw American made mines in their collection.

My visit to this museum sticks with me to this day, and my desire to promote it is perhaps out of place on this specific topic.

I stand by all of my other links as being directly relevant.

cariaso··on Problems with Object/Relational Mapping (2006)
True, but the comment I'm replying to says

I'd be interested to hear the author explain what "regular violations of nearby Laos and Cambodia" actually means.

The same bombing campaign hit both countries similarly. Laos seems to have been slightly worse off, but the concept applies to both countries. The information at the museum in Cambodia will broadly inform the Laos situation. Besides if there is a similar resource in Laos I'm unaware of it.

cariaso··on Problems with Object/Relational Mapping (2006)
In case the author doesn't show up, I'll offer

"There were more than 580,000 bombing missions on Laos from 1964 to 1973 during the Vietnam War. That's equivalent to one bombing mission every eight minutes, 24 hours a day, for nine years. Over two million tons of ordnance was dropped on the country, with up to 30 per cent failing to explode as designed."

http://www.maginternational.org/the-problems/the-uxo-problem...

More than 40 years after the war, one-third of the country is still contaminated by unexploded ordnance — an ongoing cost of war that affects the Lao people daily.

video at http://abcnews.go.com/International/americas-secret-war-laos...

also a worthwhile visit http://www.cambodialandminemuseum.org/

There may be many other violations, but I think that's a credible start.

cariaso··on Nearly 1 in 3 drugs have a significant safety issue after FDA approval
Stevens–Johnson syndrome seems to occur as a response to several different drugs, but apparently only to people with a specific HLA genotype. Part of the solution here is that currently we only approve a drug if it is safe for nearly 100% of the population, even if it is useful for far fewer (see statins) and the path forward needs to give more consideration of the differences in people, and having suitable genotyping a prerequisite for some medications.
cariaso··on Every neuron potentially has a different genome than those it's connected to
Such as?
Page 1 of 3Next →