532 karma · joined May 1, 2015
https://github.com/brian-yu https://brian.lol
[ my public key: https://keybase.io/brianyu; my proof: https://keybase.io/brianyu/sigs/TCCFPVwBuv1kBlfE_OqHSejthDfX-ESgtq4aWopT8Yg ]
I was playing around with codex this weekend and honestly having a great time (my opinion of it has 180'd since gpt-5.2(-codex) came out) but I was getting annoyed at it because it kept missing references when I asked it to rename or move symbols. So I built a skill that teaches it to use rope for mechanical python codebase refactors: https://github.com/brian-yu/python-rope-refactor
Been pretty happy with it so far!
[0]: https://www.llnl.gov/join-our-team/careers/find-your-job/0d6...
I found it incredible how several of the siblings are now well-known artists[0]! What a life these people have led.
[0]: https://en.wikipedia.org/wiki/Warlimpirrnga_Tjapaltjarri
Apparently a normal human heart weights 10 ounces[0]. That means Dom Pedro's heart is 32x the weight of a normal heart! Can all that extra weight truly be caused by tuberculosis alone?
[0]: https://my.clevelandclinic.org/health/body/21704-heart#:~:te....
But for me, upvote and comment counts bias my perception of a post. I'm choosing to hide these counts so I can read articles uninfluenced by the number of points they have relative to other posts on the front page.
After hiding upvote and comment counts, I've found myself reading more of those high-quality niche articles that I wouldn't have clicked on previously. I've also found myself reading post titles more thoroughly and reading articles first instead of immediately jumping into the comment section to get summary/judgement.
Perhaps this extension is unnecessary if you have more self control that I do ;).
This quote in particular gnaws at me: "We had promised each other that in a few years, when the girls headed off to college, we’d work less and travel more. Amy didn’t deserve to lose those dreams, or her companion, just as we were on the brink." I, presumably like many others here, have spent a lot of time on my career, perhaps to the detriment of other aspects of my life. Is it worth it? That seems like an impossible question to answer.
[1]: https://www.wired.com/story/lee-holloway-devastating-decline...
> "Most of the active projects are in exploratory or preclinical stages. However, 5 candidates have recently moved into clinical development, including mRNA-1273 (Moderna), Ad5-nCoV (CanSino Biologicals), INO-4800 (Inovio), LV-SMENP-DC and pathogen-specific aAPC (Shenzhen Geno-Immune Medical Institute). Notably, Moderna was able to start clinical testing of its mRNA-based vaccine just 63 days after sequence identification."
Presumably, those are 5 out of the 8-10 that Gates thinks is promising
[1]: https://cepi.net/news_cepi/cepi-publishes-analysis-of-covid-...
17,000 ns of simulation per day sounds crazy small but I wonder how that compares to the timescale of molecular interactions. How helpful have Antons been to pharma research etc?
"In 2012, an Australian tourist named Dennis Ward was kicked off a cliff into a body of water by a cassowary when he and his family were visiting Babinda Boulders in Queensland. 'It just came straight up to me, decided to pick on me for some reason, I don’t know what for,' Ward told the Cairns Post."
I shouldn't be laughing but that is an outrageous story.