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The technique definitely applies to other artifacts! The core pipeline we call Virtual Unwrapping and has been used to successfully reveal some ancient texts[1]. The primary challenge in this post is addressing the "carbon ink problem" specifically, where the ink looks identical in density to the uninked papyrus. But some artifacts make it easier, for example they are written with iron gall ink which shows up quite clearly in X-ray CT.
[1] https://advances.sciencemag.org/content/2/9/e1601247.full
The micro-CT machines currently available are either optimized for smaller object sizes or for lower resolutions. The challenge is to build a machine that can scan a "large" object such as an entire scroll at a high resolution. The above comment is saying that you could design and build such a machine using components currently available (expensive, but possible).
That's not the sole obstacle though, next you have to extract the information you want (visible text) from the resulting data. There are some more challenges here yet to be solved, notably segmenting out the individual layers from each other. This is particularly hard with the Herculaneum scrolls, as there are often hundreds of layers all smashed together, and they are wrinkled and warped. But we're working on this too!
Edit: as for the contents, it could be just about anything from the time period. Many of these scrolls have been opened manually over the last two hundred years since their discovery. This has largely destroyed them into thousands of fragments, but in many cases has revealed some text, so we know some of the contents of the library. Much of it is by Philodemus, who was an Epicurean philosopher but not particularly notable. It is believed that there could be more scrolls from other sections of the library still buried, as much of the town is not excavated. If it is shown that we can indeed read the contents noninvasively, it might be an incentive to dig up more of them and see what is there.
There was a collection of papyrus scrolls in the Villa dei Papiri there, which were carbonized by the ash. They were damaged and preserved at the same time by the eruption, so we still have many of them today but the intact scrolls fall apart if you try to open them by hand (similar to trying to unroll a piece of charcoal).
I have been working for a while on a research team that is attempting to read these scrolls noninvasively using micro-CT. The materials of this particular collection are the perfect storm of challenges for this approach, but we are chipping away at the problem. It has been quite a lot of fun to work on. Should anyone find it interesting, here[1] is some of our work from earlier this year, showing a proof of concept on how we can distinguish carbon ink from carbonized papyrus in X-ray even though they appear identical at first.
[1] https://journals.plos.org/plosone/article?id=10.1371/journal...
0: https://www.lesswrong.com/posts/xg3hXCYQPJkwHyik2/the-best-t...
Edit: I have not read this book or any others in the domain, just wanted to add some context I did not already see in this thread.