bijection

Short of frequent blood donation, is there any reasonably adoptable life change a person can make to meaningfully reduce expected PFAS intake, or is it best to try not to think about it?

Ha55ii's powder game is perhaps the best of the genre, and the ease of sharing made for a pretty cool online community circa 15 years ago. I remember various calculators / computers created in powder game, along with a bunch of artistic efforts.

Though I agree that inequality is less important than the quality of life of the poorest people, this article explicitly tries to characterize the latter, so even though this is done in the name of discussing wealth inequality, I'm not sure your comment applies here.

I was just starting a comment on this but you beat me to it! I believe

  contain: strict;

on the parent element would have been sufficient here.

How does this compare to relace, which I believe is also a YC company? They seem to have very similar functionality [0]

[0] https://www.relace.ai/

The linked article covers this - the main innovation is neither the HIV activation treatment nor the general mRNA-wrapped-in-lipids (LNP) delivery mechanism. Instead, it's a new form of LNP which works on specific white blood cells that were hard to target before.

  It was “previously thought impossible” to deliver mRNA to the type of white
  blood cell that is home to HIV, said Dr Paula Cevaal, research fellow at the
  Doherty Institute and co-first author of the study, because those cells did
  not take up the fat bubbles, or lipid nanoparticles (LNPs), used to carry it.

  The team have developed a new type of LNP that those cells will accept, known
  as LNP X. She said: “Our hope is that this new nanoparticle design could be a
  new pathway to an HIV cure.”

I built a similar thing that includes forces between particles meant to simulate a sort of fluid or, as you scroll down, a gelatinous solid. There’s a bit of free energy injected to keep things moving so it’s actually a very bad fluid sim, but I think that makes it a better interactive toy in exchange.

One of the fun parts of naively n^2 particle simulations is trying to find ways to reduce the algorithmic complexity of collision detection. I remember messing with sweep lines and similar, though I don’t remember what optimizations made it into the final code. [0]

[0] https://omrelli.ug

I have a particle simulation type thing on my website: https://omrelli.ug/

It was supposed to be a fluid simulation, but it’s slightly broken in ways that I thought made it more fun. I made as a hobby project many moons ago.

These days there are similar looking things you can add to a site with a line or two of includes, but I think mine remains a little more sophisticated.

It’s interactive, and scrolling changes the simulation parameters.

I've finally switched (back) to firefox today.

I switched from firefox to chrome for their superior devtools a few years back, but hopefully firefox has had time to catch up.

Everything old is new again!

I'm not super familiar with KYB, so it could be that this would pass a human check as well, but I got in with a couple of mostly-blank utility bill / AOI templates and a pastebin saying 'this is the company x website, we do business y' as the official company website.

In any case this is a cool demo, and the type of thing that I expect to be mostly solved as LLMs get better. Good luck!

If you generated this with an LLM, you might consider labeling it more clearly. Wrote copy-and-pasting of llm outputs seems contrary to the ‘thoughtful and substantive’ north star of hacker news comments. And just in case I’m wrong, apologies - it would be a good bit of irony if I turned out to be the one hallucinating.

For the intrepid, especially those annoyed with the purported input-sluggishness of musescore et al, an interesting text-based alternative is LilyPond https://lilypond.org/

My dad wrote an opera using LilyPond in vim, though I believe these days he's actually doing more with supercollider, which skips sheetmusic and goes right to sounds: https://supercollider.github.io/

This Voltaire quote is misleading. He continues: “… one would imagine this piece to be the work of a drunken savage. But amidst all these vulgar irregularities, which to this day make the English drama so absurd and so barbarous, there are to be found in Hamlet, by a bizarrerie still greater, some sublime passages, worthy of the greatest genius. It seems as though nature had mingled in the brain of Shakespeare the greatest conceivable strength and grandeur with whatsoever witless vulgarity can devise that is lowest and most detestable.“

So while he is pointing out the crassness of the work, he does think it’s great. Voltaire was very interested in the English, and pointing out the contrast here was definitely coming more from curiosity or even admiration than from dislike.

We’re hiring frontendy full stack engineers here at Farallon capital, located in the SF Financial district. If you’re departing Stripe and looking for new opportunities drop me a line at gw@farcap.com

We buy them wholesale from various Chinese manufacturers. I believe the first ones were through Alibaba or Ali Express.

A friend and I manufacture a laser party light that makes your feet glow in a space smaller than most garages.

Just a 3d printer, some custom cut metal pieces, the actual electronic components and some soldering irons. [0]

[0] https://toeglo.com

Farallon Capital | Full Stack Software Developer | Full-Time | San Francisco ONSITE | https://www.faralloncapital.com

Join a small team including me and https://news.ycombinator.com/user?id=antimatter15 [0]!

We're working on an ambitious software project to revamp the investment research and monitoring experience at a storied financial firm with $40 billion of assets under management.

We iterate quickly, in close consultation with our users, and typically deploy multiple times a day. Our day-to-day challenges include implementing complex financial concepts and interfacing with everything from legacy financial software to cloud-based apps and services. We develop on Windows but come from Mac / UNIX backgrounds, and favor a more functional-programming style, though we value flexibility over dogma.

Most of our codebase is in Typescript/Node.js/React (excepting a few python components and some C# code that talks to Bloomberg).

We're offering all-cash comp (base+bonus) competitive with FAANG total comp at similar levels, with great benefits.

Email me at gwebster@farcap.com

[0] Some other stuff we've made:

237 points: Show HN: G9.js – Automatically Interactive Differentiable Graphics https://news.ycombinator.com/item?id=12572412

727 points: Show HN: Tesseract.js – Pure JavaScript OCR for 60 Languages https://news.ycombinator.com/item?id=12694004

628 points: Show HN: Carbide – A New Programming Environment https://news.ycombinator.com/item?id=12355102

1055 points: Project Naptha: a browser extension that enables text selection on any image https://news.ycombinator.com/item?id=7629396

Dupe of https://news.ycombinator.com/item?id=30260939

I posted this as a show HN a few weeks ago, I maintain a small, completely free html/js game. There's no chance of it ever making money in its current form, it's just a fun waste of time with a few hundred players[0].

[0] https://wallsmash.com

No idea if this could be financially viable. It’s essentially free to host so profit hasn’t mattered much so far.

Hi HN! A few friends and I created WallSmash years ago for our own amusement. We've been occasionally tweaking it ever since, and recently it has picked up a few regular players.

Probably the most interesting parts were working out the collision physics to be frame-rate-independant, making the drawing loop, and playing with the particle effects on collisions. Happy to answer any questions or entertain feature requests here :)

Although I don't know whether lab grown meat will be cost-competitive with traditional meat in the near future, the article's thesis "Lab Grown meat will never be cost competitive with traditional meat" assumes a few key points that seem non-intuitive, and makes me wonder if the article is written in good faith:

  > The cost of a lab-grown meat facility is comparable to a slaughterhouse.

The footprint and cost of a slaughterhouse does not include the footprint and cost of the places meat is actually grown. The article notes the lab is 'slightly cheaper' than a slaughterhouse - when you add in the space and facilities needed to raise cows I suspect the cost gap significantly increases.

  > Lab grown meat would have to be produced in Class 8 clean rooms.

My understanding is that clean rooms have much higher standards than other food processing facilities. Cell cultures today are grown to be studied in tiny amounts so small amounts of contamination need to be strenuously avoided. If we're instead concerned with the volume of production, I'd expect any amount of dirtiness below the incredible filth of a slaughterhouse is likely a win.

  > There will be no advancements in cell density of lab-grown meat.

The article assumes lab grow meat will continue to be grown as a single cells in culture. While this is the state of the art today, I'd expect many companies and labs are hard at work on denser strategies. As the article capitulates, cultivated meat could be economically viable "[when] companies can make cells grow beyond certain widely recognized biological limits. Higher cell density means more meat per batch, which in turn means the number of bioreactors can fall, and the size of the clean room can shrink."

All together, I think lab-grown meat is a lot less of a certain-failure than the article seems to suggest.

You could argue that the apis in question are more mature now than when Node was first released.

Either way, if Deno is one day replaced by something else, say 'Done' to keep the naming convention, that won't refute the use everyone will have gotten out of Deno in the mean time, in the same way that Deno doesn't refute the use everyone has already gotten out of Node.

You're mistaken. Bannon said:

"Second term kicks off with firing Ray, firing Fauci. Now I actually want to go a step farther ... I’d actually like to go back to the old times of Tudor England. I’d put the heads on pikes. I’d put them at the two corners of the White House as a warning to federal bureaucrats"

Previous discussions:

3 months ago: https://news.ycombinator.com/item?id=23955527

2019: https://news.ycombinator.com/item?id=19963640

What about perimeter vs area but let coastlines be counted as straight lines?

It's a pragmatic thing. Telling an imposter syndrome sufferer that they have imposter syndrome is more productive than telling an imposter they're an imposter. On the internet when you can't be sure which person you're talking to, it's better to give advice that could be helpful if it turns out to apply to the person you're talking to, than to share commentary that wouldn't be too helpful either way.

I think the complaint is about attribution. If a friend takes you to the park to watch the cranes and ducks, it would be a stretch to call them a great artist for facilitating that potentially sublime experience, because anyone could have taken you. Similarly Pollock's paintings may be aesthetic, but if they are easily imitated, it's hard to argue the works themselves make their author a great artist.

To be fair to Pollock, he had the creative insight to make his work in a less permissive period of art, so it's fair to argue he was a great innovator or artist on that merit, but it's a different type of achievement vs 'timeless' pieces of art like (imho) Bernini.

Is there a meaningful difference between a government withholding basic income in a UBI world and a government fining away some traditional income in normal capitalism?

From Wikipedia: CGTV "is an international English-language news channel based in Beijing and is also referred as a mouthpiece of Chinese government." [0]

[0] https://en.wikipedia.org/wiki/CGTN_(TV_channel)