alextheparrot

If I had to guess the airport doesn’t make money just off of the flights, they also provide general services to passengers. Having a 30 person flight come through might net them parking, drinks, duty free revenue as well. Even some of the aero revenue like fuel or jet bridge usage are dependent on the number of flights.

Given that, the price for how much you charge an airline should take into account how many additional passengers they will bring through their doors. There has to be a price for lower frequency/more spikey carriers, but it is probably a good bit higher and could mean it is better to just run more flights.

Wonder if that’s a fake account creation edge using that, if that signal is interpreted that clearly. Setup a bunch of fake emails, upload your “contacts” to some compromised accounts, have them click on links in the emails to enroll in FB.

Listened to "Tuesdays with Morrie" [0] over the break, which is a series of interviews and reflections by the author as he interacts with his professor dying of ALS. That and "When Breath becomes Air" [1] are both pretty astounding long-form explorations on impending death.

Hard topic, but I suppose that's the nature of it.

[0] https://www.goodreads.com/book/show/6900.Tuesdays_with_Morri...

[1] https://www.goodreads.com/book/show/25899336-when-breath-bec...

Consistency of configuration is a big thing — I can configure my Spark, internal framework, and application logs in the same file, for example. That’s actually one thing I liked about Java, how easy configuring logging via Log4j was and how widely adopted it was by most dependencies.

In terms of features, one that comes to mind log rotation.

I dunno, I suppose all together I’d answer your third paragraph to the affirmative — I’m more productive and the libraries improve significantly within crucibles like this.

Would this work with server side rendered applications? We SSR a lot of the data calls, as the identifiers to be fetched is usually available in the URL.

——

Nvm, I see that’s listed as a React Query feature.

Probably regurgitating it from the Weinstein stuff.

https://uncancelclub.com/bret-weinstein-1/

Thanks for the post, just a heads up the localForage link in your blog post leads to a 404 page.

How the relevant lesson from the original post was “Actually, you can scale pandas these days” eludes me.

Is it really necessary that we assume a precursor must be a strict equality in all dimensions aside time?

Was just going to say how much I loved it, guess that’s art.

Loyal | San Francisco, CA | Remote or Onsite | Competitive salary + equity package | (Very) Dog Friendly Office

We're working on interventions to lengthen the healthy lifespans of dogs. You'd be joining Loyal at an exciting time, we have an active drug development pipeline [0], some of our compounds were recently selected by the National Institute on Aging's Interventions Testing Program [1], and we've partnered with organizations like the Morris Animal Foundation [2].

On the computational side, we're building a platform for community science, operationalizing public data, and solving internal data workflows. You will see your work directly impact the development and deployment of longevity treatments.

We're currently hiring for a variety of roles:

- Frontend Engineer (NextJS)

- Full-Stack Software Engineer (Python/NextJS)

- Data & Infrastructure Engineer (Python, Terraform)

- Data Scientist (Python)

- Bioinformatics (Python)

If you're interested in longevity (Whether for these roles, or in general), please feel free to reach out to me directly - lampe@loyalfordogs.com or view some of our roles at https://loyalfordogs.com/careers. Domain expertise in biology is not at all required.

[0] https://loyalfordogs.com/the-science/pipeline-current-studie...

[1] https://loyalfordogs.com/nia-itp

[2] https://www.morrisanimalfoundation.org/article/loyal-dog-agi...

Loyal | Software Engineer, Data Engineer | San Francisco, CA or Remote (US) | Full-Time | https://loyalfordogs.com

Loyal is an early stage company developing drugs [0] to help dogs live longer, healthier lives. We see aging as a disease that is able to be slowed and improved with medicines. Loyal was spun out of Laura Deming’s The Longevity Fund and is well funded by top venture capitalists and angels.

We are currently a small team of engineers with both traditional tech (Apple, Github) as well as biotech backgrounds (Neuralink, Coda, 20n). We're working on everything from consumer-facing products (Connect your Dogstagram as part of our citizen-science platform) to developing data and operations pipelines to enable basic research in aging [1]. We recently licensed IP around an epigenetic clock to quantify biological aging in mice, dogs, and humans that we are excited about as well [2]. All in all, there's a lot of room to make a significant impact, while also having a Slack filled with dog pictures.

Some technology keywords:

Frameworks and Tools: Django, NextJS, Docker, Airflow, Jupyter Notebooks

Languages: Typescript, Javascript, Python

Infrastructure: AWS, Postgres, S3, ECS, Terraform

Sound interesting? Feel free to send me an email (lampe@loyalfordogs.com, please mention HN in the email) or check out our careers page at https://loyalfordogs.com/careers.

[0] https://loyalfordogs.com/the-science/pipeline-current-studie...

[1] https://loyalfordogs.com/the-healthspan-study

[2] https://loyalfordogs.com/ideker-morris

We should respect honesty more. At least then we can talk about the real issues, like maybe finding relationships in a non-work context.

We can call this person selfish and attend to the root malice only because they were honest. If they just contrived a reason to further their goal state, then they are being both duplicitous and selfish, which seems to be something we should respect less?

Paper has some flaws, but this is a good seed point.

https://www.pnas.org/content/110/15/5802?sid=98dc0a8b-4443-4...

IQ:

https://www.pnas.org/content/pnas/suppl/2013/03/07/121877211...

They’d probably argue that this same model works for that - you just update the manifold. That’s probably fair, the model isn't really powered to be predictive just correlative.

It still embeds some of the same problems, though, mainly how an individual actually interacts with it and why their interpretation is correct.

Has anyone actually read the paper?

I have some pretty serious qualms with the topology traversal routes over the DOSI vs age manifold — they seem unfounded. This isn’t inherently problematic, but that seems like a core assumption - that the steepness and thus likelihood of falling off the DOSI associated cliff increases with age. The idea being once you fall off the cliff you die.

I don’t think it is a bad hypothesis, it just isn’t a result?

They renamed DOSI from “Age independent mortality” and changed the traversal examples since their 2018 paper [0] - honestly I don’t know how this paper has gotten so much press this week. It is only interesting for the title (Might’ve answered my own question there), but once you dig into it isn’t all that rigorous.

[0] https://www.frontiersin.org/articles/10.3389/fgene.2018.0048...

Whatever keeps your dog's body mass down [0].

[0] https://newscenter.purina.com/LifeSpanStudy

I’ve been recommending The Gene to people who are just generally interested in this sorta thing

Sadly, I don't have a book to recommend.

Most of the targeting today is happening through antibodies, but the majority of LNP delivery at this point is done passively without targeting mechanisms on the LNP (Needle injection point aside).

That's actually one advantage of CRISPR over just injecting mRNA - you can target specific cell-lines (Even if you change the genome of many cell types) by using cell-specific promoters for the edits you make instead of relying on surface affinity based targeting of the LNP.

Interesting resources:

[0]: https://www.nature.com/articles/nrd.2017.243 (General review 1)

[1]: https://www.frontiersin.org/articles/10.3389/fmolb.2020.5879... (General review 2)

[2]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498813/ (PCSK9 target again, but via siRNA actuator)

[3]: https://genomebiology.biomedcentral.com/articles/10.1186/s13... (Example of cell-specific CRISPR integration)

Lipid nanoparticle delivery vehicle is really simplifying a lot of therapeutics. Looking forward to seeing Moderna and Acuitas continue to build out the platform for more targeted or effective actuator delivery.

This is actually a bit amusing, because one of my favorite reading features on iPad is being able to click and hold on an arbitrary word to look it up.

Sure, the UI/UX of a traditional link isn't desirable, but I do want every word to be linkable to the dictionary.

It’ll be a few years before we move off petrol.

This is where I think the original data admins were deluding themselves. Expecting 1,400 analysts to write better code is a really non-trivial problem, but easy to proclaim.

An actual solution is creating pre-joined tables and having processes ("Hey your query took forever, have you considered using X?") or connectors (".getPrejoinedPatientTable()") that make sure those tables are being used in practice.

Anyone who edits photos in Lightroom understands that modern photography captures both reality and artistry.

My goal when editing photos is to make them more clearly express how I felt or how I saw. This is often quite divorced from what shows up on the back screen of my camera.

This was compared to a local run ISP that they connect to via a local tower (Farm silo). The ISP licenses spectrum from Verizon iirc.

Yeah, they were getting 8 down 3 up in a rural area via a locally run ISP. Starlink is insanely disruptive in that market.

You might be interested in https://youtu.be/m05abdGSOxY, for some (long) routes it can theoretically be faster.

None that she has mentioned, though I don't think they’ve had any really really bad storms this year.

My mother was raving about the service the other day.

Speeds are 10-15x faster, she’s having an easier time with her online community college course and her job KPI is up by double digit percents [1]. She was worried that IT wouldn’t be OK with it when I said it was satellite (They’d been burned too many times), but the IT guy was incredibly excited because he’s also waiting to get Starlink.

Looking forward to the service only getting better, really incredible execution.

[0] My dad went on the roof in the cold Wisconsin winter to put it up.

[1] Lines transcribed per hour, as a medical transcriptionist working from home.

Thanks for letting me know, ordered a crate for pickup next week (Seems that they are doing well selling them in general)!