I have some pretty serious qualms with the topology traversal routes over the DOSI vs age manifold — they seem unfounded. This isn’t inherently problematic, but that seems like a core assumption - that the steepness and thus likelihood of falling off the DOSI associated cliff increases with age. The idea being once you fall off the cliff you die.
I don’t think it is a bad hypothesis, it just isn’t a result?
They renamed DOSI from “Age independent mortality” and changed the traversal examples since their 2018 paper [0] - honestly I don’t know how this paper has gotten so much press this week. It is only interesting for the title (Might’ve answered my own question there), but once you dig into it isn’t all that rigorous.
[0] https://www.frontiersin.org/articles/10.3389/fgene.2018.0048...