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A gorgeously illustrated deep dive into the immune system that will forever change how you think about your body, from the creator of the popular science YouTube channel Kurzgesagt—In a Nutshell

Immune: A Journey into the Mysterious System That Keeps You Alive

by Philipp Dettmer

Wow - this is a great read, reminds me of the guy on YouTube that used a genetic algorithm to evolve wind turbine blades which outperformed traditional ones.

Cytokines are signaling molecules used by the immune system, there are around 20 of them with names like IL-4 and IL-10. The IL stands for inter leukin (signal between white blood cells).

T Cells start as B Cells and then graduate from Thymus school after rigorous coursework (mainly don’t target and attack self). Most T helper cells stay as Th0 or undifferentiated. Th1 are specialized for inter cellular pathogens (bacteria and virus), Th2 broadly speaking are specialized for intra cellular pathogens (helminths and parasites).

Pathogens that have been around for a while like bacteria, virus, helminths, and parasites have evolved to push back against immune systems to varying degrees.

Source “The Body” by Bill Bryson

I really like this, a few comments

Why not have the homepage be the checklist? Seems odd to have a page that says click here to see the checklist

Can you send this to the one guy on our Zoom calls who logs in 3 minutes after meeting starts, futzes around with camera/microphone/sound for 5 minutes and then 8 minutes into the call announces he’s online and wants to be filled in on what he missed?

From video production the one takeaway I have is key light vs backlight, webcams like key light and webcams struggle with back light

I was a former Mint user and switched to PersonalCapital which in my opinion is a much better Freemium product than Tiller, with PersonalCapital there’s an option to pay for financial advisor or just use dashboards from the free version

Agree, I think a better process might be

- interview 40 users over zoom, gain insights, test assumptions, create hypotheses

- create sketch of product, wireframe or prototype and get feedback from 60 users on a site like UserTesting.com that produces granular insights

- hone in on problem space, understand user pain points through research instead of guessing in a vacuum

Any successful flying platform will start with a mission that includes payload capacity, range (distance), operating costs, and weather resilience.

The difference between a hobbyist and a professional is that the hobbyist builds a platform first and looks for a mission/customer after spending R&D dollars. The professional starts with a mission/customer before proceeding to R&D.