Spod_Gaju

If this is true they altered zinc metabolism might play a role in dementia since zinc is the cofactor for PDE5, or that people who do not make enough cGMP are prone to dementia (which also means they might be low in GTP and GTP regulates glucose-insulin secretion so...)

So I think they can do better then "here is a pill give me more money".

I am this way as well. People do not realized that the cannibinol (CB1, CB2) receptors can be overly sensitive in some people. Haveing a lot of ATP and GTP will tend to do this since ATP and GTP sensitize all the g protein coupled receptors.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461403/

Smoking pot makes me literally curl up into a ball on the floor in panic and anxiety.