127 karma · joined July 10, 2020
Gemini output: Research is exploring nicotinic acetylcholine receptor (nAChR) agonists as a potential non-stimulant treatment for ADHD, sidestepping the issues of pure nicotine's high addiction liability.
The mechanism focuses on boosting dopamine (DA) and acetylcholine (ACh) release in brain areas governing attention and executive function, primarily by targeting the alpha4beta2 and alpha7 nAChR subtypes.
The goal is highly selective compounds that target the cognitive benefits (linked to alpha4beta2) while avoiding undesirable side effects and addiction pathways.
Selective alpha4beta2 Agonists (e.g., ABT-418, ABT-894/Sofinicline): These were developed to strongly activate the receptor most associated with DA release. Pilot and Phase II studies showed a signal of efficacy in adults with ADHD, with effect sizes similar to non-stimulant medications like atomoxetine.
Varenicline (Chantix/Champix): This is a partial alpha4beta2 agonist, FDA-approved for smoking cessation. Smaller trials suggested improvements in ADHD symptoms, but large-scale development for ADHD has been limited or terminated, and it is not approved for this indication.
Bupropion (Wellbutrin/Zyban): An established non-stimulant ADHD treatment (NDRI) and smoking cessation aid. While its main action is norepinephrine-dopamine reuptake inhibition, it also acts as a nicotinic receptor antagonist (blocking it), which is believed to help reduce nicotine craving. It is an approved non-stimulant option for ADHD.
I would love a simple mobile app, it's just easy to tap your news app on a phone, ideally with a way to customize the notification timing. I have certain moments each day when I want to consume this type of content (breakfast, lunch break)
A small community driven comment section with Karma system would also be nice. I like to discuss news and it enables knowledgeable people to add some additional insights. See the dutch tech news site for inspiration. they explain their karma system here: https://tweakers.net/info/faq/karma/#tab:1-2
Its been going on for some time. Something that was once a joke in good jest AKA Google's graveyard, is now their actual reputation, and helping their strong big tech competitors when competing on new services.
db112nl@gmail.com Why wasn't Blockchain a watershed moment but chatGPT is.
There are several factors that contribute to why blockchain and chatGPT have had different impacts on their respective fields.
Firstly, blockchain technology has had a significant impact in certain areas, particularly in the financial industry, where it has been used to create new forms of digital currency and facilitate secure and efficient transactions. However, it has not yet achieved the widespread adoption and transformative impact that some had predicted. One reason for this may be that the technology is still relatively new and complex, and many organizations are still trying to figure out how best to implement it.
In contrast, chatGPT is a language model that has been designed to understand and generate natural language text. This technology has been more widely adopted because it has a broad range of potential applications, from customer service chatbots to language translation services. Additionally, language is a fundamental aspect of human communication, which makes the potential impact of language models like chatGPT more readily apparent to people.
Another factor that may have contributed to the different impacts of blockchain and chatGPT is the level of public attention and interest. While blockchain has received significant media coverage, it has not captured the popular imagination in the same way that chatGPT has. ChatGPT has been widely publicized and has even been featured in news articles and talk shows, which has helped to raise awareness and generate interest in the technology.
In conclusion, the differences in impact between blockchain and chatGPT can be attributed to a range of factors, including the complexity and novelty of the technology, the level of public awareness, and the broad range of potential applications.
My understanding is "tech enthousiast" level, so happy to learn.
I can also remind the old forum rules like: "No useless posts. This includes: Necroing, Thread bumping, useless one liners, Flamewars, Trolling and Spamming."
The above is no longer an issue in the more modern forum ranking methods in combination with nesting. Its frankly just sub-par any way you slice it, since the new ways have the features of the old and add to it. There is no regression only progress, you could argue.
Decentralized tech would never be where it is today if it weren't for investor attention and the potential for gains. We just have to separate the wheat from the chaff, and remain vigilant for bad actors.
I feel we finally have a privacy respecting browser normal people and tech enthousiast can use, and it puzzles me how it's painted here. let's stay objective
if you don't like the web3 stuff or the blockchain based rewards don't use it. But the web3 space is booming and brave has been nice way to interact with it.
What got me interested is that Bitwarden is open-source and empowers you to self-host, which for me goes a long way for establishing trust. It has a modern interface through desktop, browser extensions and CLI. You can choose to cloud-host your vault on bitwarden servers, for convenience, with a very generous free tier. Which is what i've been doing for years now, no complaints really.
Meanwhile crypto remains an enabler of a new application paradigm, a decentralized one.
We are now in the dotcom crash of crypto. Lots of hype has created a bubble, but from the ashes the phoenix might rise.
If you are a tech enthousiast, be happy that lots of research and development in an exiting new space was funded! If you are an investor, be happy that your investor accumen is being put to the test, which projects will flourish?
It turns out that Waiting for Godot is a play by Samuel Beckett in which two characters engage in a variety of discussions and encounters while awaiting the titular Godot, who never arrives..
So weird for the hackernews audience to hate on this mans idea's so much. Its worth a shot no?
Elon Musk is often hailed a hero for paradigm shifting to reusable rockets and wanting to use this to colonize mars. But try and do a paradigm shift in physics, out of pocket, and the haters come out in droves.
I say let the man have a go at it. We might learn something!
I dont get why people wanna frame wolfram so badly as a negative arrogant actor.
He is answering viewer questions, his subscriber audience is ofcourse asking certain wolfram physics related questions. Timestamps: 00:00 Start stream 1:49 SW begins talking and introduces Wolfram Institute 22:58 Do you have a sense of the skills that an incoming fellow to the Wolfram Institute will have? What would effective preparation for Institute-type work be? 29:23 What is the emerald functionality that was mentioned for biological/cellular computational explorations? 32:55 and what about around the world overseas and in other countries? 33:05 You get some wonderful things out of pursuing science just for the sake of it. There are pejorative terms for this, like 'fishing trips' and 'stamp collecting', but such pursuits led to PCR technology just because someone was curious about thermophile bacteria 44:53 activity overseas & in other countries in regards to outreach programs in cooperation with education systems...you were mentioning some campaigns you had going on 51:03 Will there be more active development on the computational capabilities of Wolfram Mathematica with the Wolfram Institute? 52:53 British physics is more Geometry guild vs American physics is more Group theory and particle physics Guild 54:08 What is your opinion about experimental mathematics and its relationship with classical "mainstream" mathematics? 1:17:05 I often hear that science needs philosophy to justify it. What are some historical examples of this? 1:32:27 i think in a lot of places in history the role of academic pursuit was that a philosopher's role, but academic pursuit has attained a large amount of "division of labor" 1:34:22 Philosophy and Mathematical logic are starting to overlap more. Tarskis Semantics relates Formal logic to topology just like math and computer langauges 1:36:22 Are there inherently philosophical ideas (i.e. cannot be turned into a scientific one like the question of motion)? Can we distinguish them outright without knowing future scientific development?
He has three long interviews on Lex Fridmans youtube channel! I greatly enjoyed watching those those.
1:[Stephen Wolfram: Cellular Automata, Computation, and Physics](https://www.youtube.com/watch?v=ez773teNFYA)
2:[Stephen Wolfram: Fundamental Theory of Physics, Life, and the Universe](https://www.youtube.com/watch?v=-t1_ffaFXao)
3: [Stephen Wolfram: Complexity and the Fabric of Reality ](https://youtu.be/4-SGpEInX_c)