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Mieroels

8 karma · joined September 16, 2015

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Mieroels··on A Single Neuron May Cary Up to 1000 Genetic Mutations
I think a lot of the mutations can be attributed to infidelities of single cell sequecing. The amplification of DNA that has to be done has a tendency to incorparate errors. If you start with a single copy of DNA then an copy error early in amplification will look like a mutation. The neuron data is compared to non-single cell sequencing of heart cells.
Mieroels··on OpenSeadragon: A pure JavaScript high-resolution zoomable image viewer
Openslide has a nice demo using OpenSeadragon. The histological slides can easily be > 100,000 pixels in width and height http://openslide.org/demo/