HNHacker News
TopNewBestAskShowJobs

Fede_V

4,422 karma · joined September 17, 2013

Researcher. Systems biology, open science, data analysis, machine learning and effective altruism. E-mail: 5a308f7e 'at' opayq.com
submissionscomments
Fede_V··on „We were chased out of SF after trying to give free Internet to the poorest“
I know this is well meaning, but it will almost certainly backfire. Senior leaders (public and private) need to be able to have confidential discussions where they acknowledge trade offs and negotiate deals: if everything was open and broadcast, you'd get a combination of constant nonstop grandstanding and highly aggressive opposition research that would look for snippets that look bad out of context.
Fede_V··on Vitalik escalates ETH 2.0 merge as miners plan a 51% attack
Beyond naked self interest - it's also completely unclear to me how it's possible to defend mining. It's literally useless work that ruins our beautiful planet to accumulate wealth. How is that in any way defensible? It's far less ethical than investing in weapons manufacturing.
Fede_V··on Vitalik escalates ETH 2.0 merge as miners plan a 51% attack
I've been moderately interested in crypto, but, I've held off on touching them in any form until a real ecofriendly alternative is in play - and I emphasize real (not a few obviously paid shills/imbecilles talking about how crypto is actually good for environment because it allocates capitol efficiently/thorium reactors etc etc).

If eth switches to proof of stake in a meaningful way, I'll definitely take a serious look and possibly start investing in that ecosystem.

Fede_V··on Coq 8.13
INRIA is an exceptional institution and is able to hire a lot of amazing talent. They were one the earliest public research institutions that had a separate career track for developers and technical staff.

It's truly a national gem. Researchers at INRIA are responsible for scikit-learn, coq, ocaml, etc etc.

Fede_V··on There’s no such thing as “a startup within a big company”
If you are a great engineer that can get a job at FAAG, joining a start up is almost never worth it from a strictly financial point of view.

17 years ago, Paul Graham was able to post this essay: http://www.paulgraham.com/wealth.html - nowadays, the compensation in tech has shifted upwards so much (https://www.levels.fyi/) - that start ups are just not competitive when you adjust for a risk premium. Finance captures this concept using metrics such as the Sharpe ratio (https://en.wikipedia.org/wiki/Sharpe_ratio) - which measures how much extra returns you are getting in exchange for the additional risk you take on. For start ups - your expected returns are lower, and the risk is very significantly higher.

Are there other great reasons to join start ups? Absolutely: several start ups are working on exceptionally cool science problems, some are solving tasks that will make a meaningful improvement in the lives of people (https://detroitwaterproject.org/, etc), some people just prefer working in a small company, you get a chance to work with your friends - but - if you are going to work for a generic SAAS company, don't accept a pay cut.

The VC that's financing your start up evaluates their investments with a spreadsheet and zero affection. Ask them how they sacrifice their own income to work on more interesting work, and they'll (politely) laugh in your face.

Fede_V··on Our brutal science system almost cost us a pioneer of mRNA vaccines
The other problem with the tenure system is that professors - even the ones that want to try cutting edge research and have tenure - cannot risk the career of the PhD students in their lab on some very speculative and high risk research that might backfire terribly.
Fede_V··on The NeurIPS 2020 broader impacts experiment
I'd rather have a section of the conference that's clearly dedicated to ethical issues in AI - or - mandating rigorous discussion in papers where it is clearly warranted (ie, anything concerning facial recognition/generation, de-identification, etc) than asking all authors to write an additional section.

NeurIPS is an extraordinarily competitive conference. Most authors will look at it as another way to potentially be rejected by a reviewer/area chair (in spite of all assurances about the process), and will write something incredibly trite and bland to make sure nobody is upset.

Another concern is that this leads to a death by a thousand cuts - it's very easy to justify asking authors to write an additional section - but - if someone with sufficient authority doesn't say no, the logical endpoint is something like the application process for tenure track positions, where you need to produce something in the order of hundreds of pages (teaching statement, research statement, cover letter, diversity statement, list of funding, recommendation letters, etc).

Fede_V··on Materialize Raises a $32M Series B
This is one of my favorite types of HN comments: admits the bias upfront, offers a meaningful technical answer, and links to relevant documents for a deeper dive. Thank you so much!
Fede_V··on Google has removed the option to disable autoplay from Mobile Chrome
Why not allow users to specify that they do not want any site with autoplay videos (in any shape) to show up in their top results? Alternatively - when Google shows a search result, indicate if the website has autoplay videos, this way I can avoid clicking it.
Fede_V··on Score matching with Langevin Sampling: a new contender to GANs
Alexia is one of the most original researchers working on GANs: she invented the relativistic discriminator (a brilliant and obvious idea in hindsight: https://arxiv.org/abs/1807.00734) which is one of the easiest tweaks you can make to instantly boost your GAN results.
Fede_V··on The most prized degree in India became the most worthless
I want to emphasize one thing: all the graduates from IITs I've worked with are truly top notch.
Fede_V··on Crypto Fund II
This is so incredibly ironic after the call to build stuff in the real world.

As I posted at the time (https://news.ycombinator.com/item?id=22913860) - talk is cheap, let's see where they put their money before we compliment them. I guess we've seen it now.

Fede_V··on It’s Time to Build
I'm quite sympathetic to a lot of what's in that blog post but... A16Z directly invests gobs of capital, and, indirectly, shapes the outlook of other VCs who follow their investment decisions, and they plow way more money into software/bitcoin than physical companies. Why? Because they are really good at what they do, and they realize that building physical stuff is really hard, and they'd rather invest in areas that have better returns.

I remember during the Theranos saga, Marc Andreessen kept defending Elizabeth Holmes over and over (he deleted most of those tweets unfortunately) - yet he was smart enough to not put any of his own or A16Z's money into Theranos. Words are cheap: let's see A16Z actually lead the way into investing in physical goods before we praise them too much.

Fede_V··on Lambda School’s Misleading Promises
This is exceptionally good. Fantastic journalism.
Fede_V··on Away’s former CEO is returning as its co-chief
The part of the original story that upset me the most is how the people she abused were underpaid and overworked customer support staff.

An incredibly strong signal of how decent someone is is how well they treat people that have no ability to help them. Even a selfish asshole will be charming and kind to the rich and powerful: if you want to see their true colors look how their reports talk about them when they aren't around, or how they treat a waiter who messed up their order.

Fede_V··on Nursing Homes in the US Overmedicate People with Dementia (2018)
A nice compliment to that article, via Dylan Matthews of Vox News: https://drive.google.com/file/d/1d6vYu_uN9keb9iiT2R5UJihA_61...

Short version: paying CNA more increases lifespan and quality of life for people in retirement homes because they are more motivated and you can hire better staff.

Fede_V··on Operations for Effective CEOs
I thought the article got better later on, but, the opening couple of paragraphs that emphasized story telling were very weak.

Senior leadership has a much better understanding of the business context and long term plan than I do, but, I have a much better understanding of the problem details in my specific domain.

What I find most valuable from senior leadership is clear feedback about how what we are doing fits in the broader context of what the company is doing, as well as specific high level feedback on the roadmap of our org.

The story format can be helpful to frame a vision of how you'd like a product launch to go, but, it's not suitable at all for most of the communication a CEO/SVP does.

Fede_V··on PIA VPN to be acquired by malware company founded by former Israeli spy
Thanks for the update, immediately did the same.
Fede_V··on Uber proposes policy that would pay drivers a minimum wage of $21 per hour
And I presume you made an utter killing by putting your money where your belief were? Because if you didn't I don't believe you in the slightest.
Fede_V··on The Tyranny of Trendy Ideas in Academia
I don't have issues with the technologies, I have issues with the early papers that came out with 'gene signatures' based on maybe 40 or 50 patients.

I think in general it's actually quite easy to tell which results are hype and which are not. Do a power analysis and estimate what kind of sample size would be required to measure the effect the researchers estimate - if they are off by an order of magnitude, reject.

Fede_V··on The Tyranny of Trendy Ideas in Academia
I am as anti-pomo/critical theory as it gets, but, sadly, this phenomena is very much present in the hard sciences as well.

For example, about 10-15 years ago, the big craze in biology was microarrays, and the early papers made crazy promises about everything that they would deliver. With hindsight, it turned out almost all the early papers were fatally flawed and were drastically statistically underpowered: it turns out that living systems have a huge amount of noise, making clean measurements is difficult, and things are very complicated. The same exact thing played out with microRNAs, epigenetics (chipSeq data is exceedingly noisy), metagenomics, single cell genomics, etc.

Every single time you'd get 'trailblazers' who'd come into the field, do shitty rushed science, hype their results like crazy, and by the time people figured out that all the initial results were garbage, they'd have moved onto the new hot thing.

I guess the advantage that hard sciences have over the humanities is that eventually we'd figure it out and do things properly - but the amount of money that has been wasted in shitty research that didn't add anything to human knowledge is probably in the hundreds of billions in the last 15 years alone.

Fede_V··on Canadian permafrost thaws 70 years earlier than predicted
I agree with this.

To the extent that we have lots of influential people browsing this forum, make it clear that unless to any politician that unless they aggressively tackle global warming, they won't get any donations/votes no matter how good they are in other areas / how much influence they have over the business you are running.

Fede_V··on Canadian permafrost thaws 70 years earlier than predicted
Global warming is the single scariest existential threat our species has ever faced, and we aren't doing nearly enough to tackle it.

Our future descendants will heap scorn and curses on our generation, and we deserve every bit of it. Every politician that refuses to do what is necessary or finds it convenient to play stupid language games about 'settled science' is doing incalculable harm.

As citizens, I encourage everyone to reducing their carbon footprint as much as possible (yes, that means that your life gets comfortable) and voting exclusively on how credible a politician is on tackling global warming. If you are a wealthy person and aren't buying carbon offsets for all your emissions, you are a bad person.

Fede_V··on Are the dead taking over Facebook?
Slightly OT, but, did anyone else get echoes of Gogol looking at the paper? :)
Fede_V··on Bullshitters: Who Are They and What Do We Know about Their Lives? [pdf]
If you've never experienced it before, the first time you work with someone who is a pathological liar and bullshitter is a completely disorienting experience. Normal people just don't lie that brazenly and with so little remorse - so you walk out of meetings wondering if perhaps you just misunderstood because there's no way someone would straight up lie that way.

Interestingly, both of the worst bullshitters I've ever met were in academia - and the business world has been a breath of fresh air in comparison. When I used to work in computational biology, I met several senior professors who lead big labs who had absolutely no understanding of any of the methods used by the grad students in their group.

Fede_V··on Defining a Distinguished Engineer
That is a very important job, but that typically falls more on the shoulders of an SDE manager, not a distinguished engineer.
Fede_V··on Instacart and DoorDash’s Tip Policies Are Delivering Outrage
I totally agree with this, and I think this makes the point that social outrage can sometimes play a positive role.

In an ideal world, we could get people to act ethically because it's the right thing to do: if we can't do that, at least we can appeal to their self interest and point out how horribly this could backfire if people found out.

Fede_V··on The Yoda of Silicon Valley
The world would be such a better place if there were 1000 more people like him. What a wonderful human being.
Fede_V··on UCLA asked faculty to consider declining to review for Elsevier journals
This is a great suggestion and I hope UCLA follows this.
Fede_V··on PyTorch 1.0 is out
Thanks for explaining that design logic a lot more clearly. I figured out what the code did, but understanding the why was very helpful.
← PreviousPage 2 of 15Next →