It doesn't matter that Republicans are slightly more to blame then Democrats in the thinning out of rural places - the folks who live there, IMO, see both parties as the same thing.
They remember how their towns were when they were young, they had a bustling locally owned and operated main street full of commercial activity, they also often had a factory, or mill which provided good jobs too.
Some of the parallel commenters here only think rural = farming, and thats not true. If you look at the Carolinas for example, there were textile and lumber mills - farming there is still more or less as healthy as its every been - but all of those other sources of employment which brought money in from outside of the community are gone.
This story repeats itself in a bunch of places, Ohio, Indiana, Pennsylvania, West Virginia, Michigan, and across the greater west too.
This rot started well before Reagan though - it's something I've called "the 1971 problem". If you go on a road trip across rural America, you'll rarely see a locally funded building (aka, not a chain store), built after 1971-3 - with the notable exception to this being places with a military base, college, or some other government facility - and I think the causes are multiple here, post vietnam drawdown of forces, détente, the 1973 oil crisis, stagflation, the Nixon shock, then later the so-called peace dividend after the collapse of the Soviet Union and the end of the cold war.
Globalization thru the 80's-90's just made all of these issues worse, and hollowed out manufacturing too - now all of this this effected cities too, to some extent, but as you mention, cities got benefits of globalization - more information economy jobs, greater wealth flowing in from the financialization of everything, which while didnt replace the jobs lost in manufacturing, did replace the wealth generated by it. (there are even more things I've not really touched on - like the steady decrease in local ownership of businesses, and the corresponding civic rot that kicks in when this happens)
There is another issue I also want to touch on here - "jobs for regular people" - for a significant portion of the population, the best job they can hope for is a decent factory job, a job in the trades - or more likely today, a not so great service job. One of the reasons I want to onshore manufacturing is that we need those higher quality jobs to ensure the benefits of our economy are shared more broadly.
I'm a proponent of tariffs as a way to solve this - not what Trump is doing which are penalty tariffs - but what I've called cost adjustment tariffs - tariffs that adjust the price of imported manufactured goods to the same level as if they were made here, where you price in labor differences overall regulatory burden, environmental and climate rules, and other factors - on a fundamental level, I feel it is immoral to export all the externalities from manufacturing to another country (pollution being the primary one I'm thinking of).
While tariffs, even at some low level may result in slower GDP growth. People cannot eat or pay their rent with GDP - a more ideal answer (one I support) is UBI, but UBI doesn't appear to politically possible - and there is also value in being able to do work where you can see the fruits of your labor (both in the physical good you've made - and the pay check you get at the end of the week), for good or for bad, it gives you self worth and a feeling of purpose too.
So I get why rural voters vote for Trump, and its because my side has failed to understand the economic pain that anyplace that isn't a tier 1/2/3 city has experienced over the last 50 years - and what their needs are for the future. In the end, I think Trump will fail them, and probably make everything else worse - but he's the horse that the American people who could be bothered to show up to vote picked (I'll note much to my consternation, that 3m less people voted in 2024 vs 2020).