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6177c40f

817 karma · joined January 11, 2020

Hello, this is my profile.

I have diverse interests, mainly biology (especially synthetic biology, virology, and mycology), computer science, and cryptography.

I can be reached at the following email, however you must decrypt it first (hint: LIMULUS):

382128752A3A3F20263A3C223273253A6D38357536212824396C3437283B28263F79733C2528343F30732A2C28396C3321292C6D212375202D306D3D29393F23692C3B28752024283F306C3C3D382C3F303F213A222E6D21243C3D2B3A637529383225256D34283121293A3E6F6C366A787A28382D3C3F0C242C3C207B302324

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6177c40f··on Big Food vs. the People
This comment strikes me as being in bad faith: "Oh so you don't like A? You must be on the side of ¬A!"

I ask, humbly, that people please not do this. Nothing good has ever come of it.

6177c40f··on How to survive boiling water
Suit yourself, I often wish I could form spores, desiccate, and rehydrate at a more appealing time.
6177c40f··on How to survive boiling water
However, to bring it full circle, Deinococcus radiodurans does not form spores!
6177c40f··on Maybe there's a pattern here?
Reminds me a quote from Gibson's Spook Country: "That's something that tends to happen with new technologies generally: the most interesting applications turn up on the battlefield, or in a gallery."
6177c40f··on Scott Adams has died
I find AI replies to generally be less annoying and more constructive than comments like this, TBH.
6177c40f··on Opus 4.5 is not the normal AI agent experience that I have had thus far
I think we might make new jobs, but maybe not enough. I'll be pleasantly surprised if we get good at sharing wealth over the next few years. Maybe something like UBI will become so obviously necessary that it becomes politically feasible, I don't know. I suspect we'll probably limp along for awhile in mediocrity. Then we'll die. Same as it ever was. The important thing is to have fun with it.
6177c40f··on Opus 4.5 is not the normal AI agent experience that I have had thus far
Sharpen sticks, hoard water maybe? We were always going to die someday, I don't see how this changes things.
6177c40f··on Opus 4.5 is not the normal AI agent experience that I have had thus far
You say this like it's some kind of ominous revelation, but that's just how capitalism works? Yeah, prepare for the future. All things are impermanent.
6177c40f··on Opus 4.5 is not the normal AI agent experience that I have had thus far
More indirection in the sense that there's a layer between you and the code, sure. Less in that the code doesn't really matter as such and you're not having to think hard about the minutiae of programming in order to make something you want. It's very possible that "AI-oriented" programming languages will become the standard eventually (at least for new projects).
6177c40f··on Opus 4.5 is not the normal AI agent experience that I have had thus far
I think we're entering a world where programmers as such won't really exist (except perhaps in certain niches). Being able to program (and read code, in particular) will probably remain useful, though diminished in value. What will matter more is your ability to actually create things, using whatever tools are necessary and available, and have them actually be useful. Which, in a way, is the same as it ever was. There's just less indirection involved now.
6177c40f··on Opus 4.5 is not the normal AI agent experience that I have had thus far
Cheaper than hiring another developer, probably. My experience: for a few dollars I was able to extensively refactor a Python codebase in half a day. This otherwise would have taken multiple days of very tedious work.
6177c40f··on Civics is boring, so, let's encrypt something (2024)
So, if we were to implement what this author is proposing, governments would be allowed to jail people indefinitely simply because they used effectively unbreakable encryption- regardless of whether what they encrypted was illegal (or evidence of a crime)? Because if so, that is absolutely unacceptable in any society that would call itself free.
6177c40f··on Why are there so many rationalist cults?
> his perspective radically to lack merit

What perspective would that be?

6177c40f··on Why are there so many rationalist cults?
I mean, as a rationalist, I can assure you it's not nearly as sinister a group as you seem to make it out to be, believe it or not. Besides, the explanation is simpler than this article makes it out to be- most rationalists are from California, California is the origin of lots of cults.
6177c40f··on Why are there so many rationalist cults?
You're right, I misread you.
6177c40f··on Why are there so many rationalist cults?
I think it's a meaningful distinction- most rationalists aren't running murder cults.
6177c40f··on Why are there so many rationalist cults?
No, the downvotes are because rationalism isn't a cult and people take offense to being blatantly insulted. This article is about cults that are rationalism-adjacent, it's not claiming that rationalism is itself a cult.
6177c40f··on Why are there so many rationalist cults?
To be clear, this article isn't calling rationalism a cult, it's about cults that have some sort of association with rationalism (social connection and/or ideology derived from rationalist concepts), e.g. the Zizians.
6177c40f··on Roman dodecahedron: 12-sided object has baffled archaeologists for centuries
I mean,

> Because these dodecahedrons have been found in Austria, Belgium, France, Germany, Great Britain, Hungary, Luxembourg, the Netherlands and Switzerland — but not in Italy — Guggenberger views them as "Gallo-Roman products" with a possible origin in the Celtic tribes of the Roman Empire.

Sounds like you might be right!

6177c40f··on Mira Murati’s AI startup Thinking Machines valued at $12B in early-stage funding
Fun fact, in the novel the computers were Cray X-MPs (sadly Cray is now semi-defunct, since they were bought and merged into HPE) [1].

[1] https://cray-history.net/2023/08/20/cray-systems-in-popular-...

6177c40f··on The Lumina Probiotic May Cause Blindness in the Same Way as Methanol
I'm not certain they're correct there, as various studies seem to quote different numbers. Either way, I'm not sure rats are so much more efficient that it would matter: e.g. if the half-life in rats was a few tens of minutes vs the hour or so half-life in humans, would that make the difference between no toxicity and toxicity? Still, I haven't seen other people report vision loss, so maybe the point is moot anyway.

Although, it doesn't preclude some kind of uncommon impairment to formate metabolism, which would explain why it doesn't happen to other people.

6177c40f··on The Lumina Probiotic May Cause Blindness in the Same Way as Methanol
Very unfortunate situation, but I'm doubtful that it's the bacteria causing it. As far as I can tell, it just doesn't produce enough formate. The body is pretty good at metabolizing formate, so it really only causes blindness from large, acute exposures, not smaller chronic exposure, AFAIK. Combine that with no other reports of blindness from other users of the Lumina probiotic, nor any similar issues appearing in rodent studies, and the bar for evidence is pretty high.
6177c40f··on Coffea stenophylla: A forgotten bean that could save coffee from extinction
Robusta is great if you don't go with the low quality stuff. Good quality Vietnamese Robusta is very enjoyable (and much higher in caffeine than Arabica, which I think is a nice bonus).

There's also the possibility of hybridizing Robusta and Arabica to get the best traits of both. A few hybrid varieties, such as Catimor, have existed on the market for a while. AFAIK Catimor has some of the hardiness of its parent Robusta.

As always, you'll have the best experience if you buy whole beans and grind them yourself (or at least find a supermarket that lets you grind beans fresh). No instant coffee that currently exists will be able to compete with that.

6177c40f··on Japanese scientists create new plastic that dissolves in saltwater overnight
Looks like it comes from the original RIKEN article [1], where they call it an "artistic rendering" instead of an "artist's impression." More accurate, I suppose, but I wish people would just actually say if an image is AI generated or not, at least for the sake of clarity.

[1] https://www.riken.jp/en/news_pubs/research_news/rr/20250327_...

6177c40f··on Japanese scientists create new plastic that dissolves in saltwater overnight
Parylene C, a chlorocarbon: [1]

> Derivatives of parylene can be obtained by replacing hydrogen atoms on the phenyl ring or the aliphatic bridge by other functional groups. The most common of these variants is parylene C, which has one hydrogen atom in the aryl ring replaced by chlorine. [2]

[1] https://www.science.org/doi/10.1126/science.ado1782

[2] https://en.wikipedia.org/wiki/Parylene#Permeability

6177c40f··on Feral pig meat transmits rare bacteria
I do that. Cook it to an internal temp of about 145 F (about 63 C). That's hot enough to kill Trichinella in an under a minute (as well as other pathogens), but the meat will still be pale pink and juicy. I've only done this with American supermarket pork though, so experiences may vary.
6177c40f··on Moscow-based global news network has infected Western AI tools
Consume multiple sources which are subject to forces with different incentives. All information is wrong, some is useful, and not everything is wrong in the same direction.
6177c40f··on Moscow-based global news network has infected Western AI tools
These kinds of semantic arguments are as pointless as they are unhelpful. There are shades of accuracy- state-controlled media often ranks lower than other sources on topics in which the state has a vested interest.
6177c40f··on IAC confirms existence of a Super-earth in the habitable zone of a Sun-like Star
Depends on the radius, as I understand it. It could have more or less gravity depending on that, but we don't know what the radius of this planet is yet.

Wolfram Alpha has a good calculator if you want to play around with this [0]

[0] https://www.wolframalpha.com/input?i=surface+gravity+calcula...

6177c40f··on If I could dissect a sauropod
Thank you, this really aligns with my interest. I'll definitely be reading more
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