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Without senses (sound, touch, taste, sight, smell), I would imagine that the human brain would create it's own little world. It's not like you're depriving it of senses it once had. It's not going to have knowledge of what being crippled is. It won't be aware that any of those 5 senses exist.

It's almost as if a human missing most of their senses spent their entire life in a float tank. I don't think it would be humane or inhumane, merely different. Without tons of advances we wouldn't be able to relate to it, or it to us. It wouldn't even be aware we existed.

In a way, its possible that the first intelligent alien life we make contact with will be one we create. As a specie, we've spend an inordinate amount of time and effort trying to make contact with intelligent life that might exist beyond our planet. Learning to make contact with artificial brains that we can hook up to different senses (artificial and mechanical or artificial and biological) is going to be awesome.

It's even possible that the brain in it's own isolation from us even does something humans do naturally; it tries to explain and understand its world and may even form the notion of a god or creator that brought it into existence. Hopefully one day it will get to meet its creator that brought it into existence. It likely won't damn us or condemn us because it won't know any better that it was crippled, just as the religious among us don't damn their gods for not bestowing us with talents and abilities like omniscience and omnipotency.

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To investigate the debate, Dr. Harlow created inanimate surrogate mothers for the rhesus infants from wire and wood.[10] Each infant became attached to its particular mother, recognizing its unique face and preferring it above all others. Harlow next chose to investigate if the infants had a preference for bare wire mothers or cloth covered mothers. For this experiment he presented the infants with a clothed mother and a wired mother under two conditions. In one situation, the wire mother held a bottle with food and the cloth mother held no food. In the other situation, the cloth mother held the bottle and the wire mother had nothing.[10] Overwhelmingly, the infant macaques preferred spending their time clinging to the cloth mother.[10] Even when only the wire mother could provide nourishment, the monkeys visited her only to feed. Harlow concluded that there was much more to the mother/infant relationship than milk and that this "contact comfort" was essential to the psychological development and health of infant monkeys and children. It was this research that gave strong, empirical support to Bowlby's assertions on the importance of love and mother/child interaction.