You're probably going to be going through some more untested ground (compared to working in straight JS if you're going for web), but I quite like working in Haxe personally, and the #haxe irc channel at freenode is very helpful :)
I think it's weird to say process doesn't matter, it definitely does, the fact that (some parts of) the gamedev world sticks almost entirely to "tested" technologies is more a sign of it's conservativeness than anything else. (okay, it's not just that (cue endless memory and performance arguments), but in large part, it really is!, okay and sure friction may be slightly less in something which is more well used, but that's not an excuse to not go for the interesting alternatives!)
So for the OP, if you want to learn an interesting, but sort of fringe language, take a look at haxe (people like: http://grapefrukt.com/) use it for game dev for example!
[0] http://haxe.org/manual/lf-pattern-matching-guards.html [1] http://haxe.org/documentation/introduction/language-features...