Raich was a terminally ill old lady, living in CA, who in compliance with state law and under her doctor's oversight, was growing 6 pot plants for her personal medical use. She was subjected to a federal DEA (Drug Enforcement Agency) home-invasion raid wherein said plants were seized.
Raich argued the legality of growing the plants for personal medical use under state law, intra-state, alleging doing so in no way affected interstate commerce and thus was not subject to federal regulation & seizure (and violently so at that).
The Court ruled that her growing her own pot for personal use did affect interstate commerce by reducing demand in an illegal interstate market.
No, I'm not kidding. Yes, they said that.
While the current federal administration may be opting for leniency in enforcing controlled substance laws, the next (1.5 years away, whichever party) may choose to resume aggressive enforcement to the limits of the law which SCOTUS has defined, which as Raich shows is very, very expansive. I suspect a, say, premium cannabis subscription club might be first on the DEA hit list.
[PS: the ruling in Raich may have been affected by the pending Stewart case, which was remanded in light of Raich. If Raich had been ruled to the reverse, Stewart would have in likewise reasoning legalized convicted felons building machineguns at home (legal under Washington state law). I'm not kidding about that either.]