>In other cases like where elements in the middle of a table are updated, you would get into a mess writing vanilla code, either complexity or performance wise, because you'd have to traverse the DOM to get to where you need to do updates and do each update individually.

If you have a table and want to edit information this is trivial to do in a React like way without React. Edit button stores reference to the row, edit values, update data store, render out new row element, remove element, insert new element. Yes, React will generally be less code and the argument becomes whether this is more complex, which it is, but I'd say neither the complexity or performance truly suffer. I bet the performance will be faster as you removed diffing entirely and React will have to perform your logic anyway.