In any event, I found that mainstream ISPs are willing to unblock port 25 if you tell them you are running a personal mail server and have it properly configured to not relay for unauthenticated users.
Aside from that, you'll want one static IP to make your life easy so you don't need to use dynamic DNS.
I think matters such as availability of your server and configuration are surmountable challenges.
But I strongly agree with you about security. Although I really like the idea of this device, the first thing I noticed in the product web page is the use of PHP Roundcube for webmail. I have a fear of running PHP anywhere on my network. The track record [1] is way better than, say, Wordpress, but seeing things like Exec Code, even back in 2008, gives me pause.
[1] http://www.cvedetails.com/vulnerability-list/vendor_id-8905/...