You might want to take a look at what the American Psychological Association and the American National Institute of Mental Health have to say about the case [0, 1], the University of Maryland's patient education article [2], Saveanu and Nemeroff's paper "Etiology of depression: genetic and environmental factors" [3], and clinical criteria (like DSM and ICD).
[0]: http://www.apa.org/helpcenter/understanding-depression.aspx
[1]: http://www.nimh.nih.gov/health/publications/depression/index...
[2]: http://umm.edu/health/medical/reports/articles/depression