How big is this cluster? Are you writing and reading to the entire cluster, or do you have certain nodes that you write to and others that you read from?
We have two clusters of 8 nodes each. Each cluster is setup with 2 factor replication. The clusters are setup with cross datacenter replication.
Your read / write question is a little hard to answer. In Aerospike, a given key will always reside on the same node, something to do with how they optimize their storage. Which means that anytime you write to, or read from, a given key your query will always be routed to the same node.
The suggested method of solving this is to have two keys, one for each cluster, and XDR both keys. Then add them together in the app. You can maybe do it through a lua script, though I haven't tried.