I've seen it used "in the wild" in this publication: "Topographical transcriptome mapping of the mouse medial ganglionic eminence by spatially resolved RNA-seq" http://genomebiology.com/2014/15/10/486/abstract (pdf: http://linnarssonlab.org/pdf/Genome%20Biology%202014.pdf ) to cluster gene expression samples from mouse brain.

I'm working on a project where I'm using similar methods, but not from Ayasdi, to study cyclic phenomena in high-dimensional data.