One thing I would likely miss living in a small forever is the intellectual input. Sure, it is nice to have exchanges through the Internet for that, but sometimes it is good to have some intriguing discussions with other driven people.

OTOH, the vibe/'cutting edge' in big cities is just a fad/false religion more often than not.

But I do think it is easier to find like-minded people or people to connect to in bigger social groups.