"Applications using Seastar can run on Linux or OSv." Will Seastar support OS X? If No, developer using Mac has to install Linux VM to development.
Intel's DPDK doesn't support Mac OS X.
You should probably develop in a VM anyways, or at least with a platform + hardware that supports these features so you can better match what production deployments will be like.
I always cringe a little, for backend systems software, when people develop in an environment completely divorced from their production environment. It just creates headaches.
Note you'll need gcc 4.9 or later.