My anecdotal experience so far is that it seems to hurt in early-stage startups. But it can be helpful in more established companies. I've worked with quite a few MBAs in both environments and it's usually been pretty painful in the small startups.
In one case, I worked at a small startup with a VP with an MBA and a CEO without. The CEO was brought in to pivot the company, and for the first couple years it was going really well - from -15% growth to +30-40%. He ended up getting rid of the VP for all the kinds of reasons MBAs don't do well in this kind of company.
But then the CEO decided to go get his MBA, and a year into it started making really terrible typical MBA style "let's squeeze blood from this stone" decisions and the company was vapor within a year.