* Can't go faster than light (or even a large fraction of the limit)
* Cost. Look at price per compute vs price to bring something to space and tell me which trend seems more durable. Things will keep getting smaller while space exploration may not.
* Space sucks! Very inhospitable. I'd rather live in a biodome on a ravaged earth than mars.
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Alternative things to spend huge amounts of money on:
* LHC and other research on very small things
* More telescopes in space (light travels at the speed of light at least! Let it come to us instead of vice versa!)
* Encouraging trend of cheaper compute (not that it needs it)
* Brain to computer interfaces.
* Medicine
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What's to say some low mass x-ray binary systems aren't the final stage of life evolution? Super efficient harvesting of the sun and everyone living in a computer/black hole? Transcension hypothesis basically.