I'll agree with you on the issues with key-rebinding for gaming and copy/paste becoming more difficult. Going back to typing Azerty/Qwerty becomes a real hurdle and this might be a problem depending on your situation.
But the pain (tendinitis or carpal, I did not check with a doctor) that I experienced after only 2 hours of typing disappeared completely. That being the goal of my change I consider the change a successful one.
I managed to learn Dvorak in 2 months, with the keyboard feeling more natural and logical during the learning period. While it took me years to become proficient with Azerty (the Belgian keyboard-standard). I accelerated my learning process with a simple CLI based typing-trainer.
TL;DR: Dvorak is more difficult in regular life but it can solve pain issues. So I recommend changing to the layout for that purpose.
*edit: spelling