"Dude" doesn't necessarily imply male, but it is strongly slanted that way. I'm not sure if it would hold up as discrimination.
Quickly Googling seems to indicate that it's not set in stone, at least.
While you might refer to a mixed-gendered group as "dudes" it seems odd to refer to a single female as a "dude"
That said, I agree it's not appropriate for a job req and understand why it turns women off from applying.