Prime 3 was a great game that would have been better with a normal gamepad. In fact, you can play it with one in Dolphin and it's an entirely superior experience.
I can't think of a single Wii game (outside the Wii Fit / Wii Sports gimmick games) that wouldn't have been better with a normal gamepad. The Wiimote is a little too clever for its own good, and as a tradeoff "traditional" games almost necessarily have to be very easy in order to compensate for the inaccuracy of the control mechanism. Even then, the Wiimote ends up being frustrating more often than not.