There are non-DND pen and paper RPGs if the wizards and warriors trope doesn't do it for you. Peter Watts pointed out Eclipse Phase[1] recently if transhumanism/singularity/horror are more your style; the PDF is legally available on various torrent aggregators if you want to try your hand without having to convince a half-dozen friends to shill out for a book.

That said I haven't actually played it yet myself, as others have pointed out getting a group of friends in different zip codes into one session is NP hard.

[1] http://www.eclipsephase.com/game

And host your campaign on my site! http://www.obsidianportal.com

See the real problem with that is I am probably neither fun nor witty and probably wouldn't be able to handle creating a fake world and exploring said world. I couldn't even play WoW when a friend bought me an account (but thats probably more heroin than cocaine).