"Patients on immunosuppressive medications have a 10- to 100-fold increased risk of cancer compared to the general population"
"Patients on immunosuppressive medications have a 10- to 100-fold increased risk of cancer compared to the general population"
It's likely that aging is a product of multiple such trade-offs. I very, very strongly doubt that SENS will be achieved by simply adjusting one or two knobs.
One possibility is that we just get really, really, REALLY good at detecting and zapping cancer, and then we turn off all the senescence-generating anti-cancer safety switches and decay mechanisms and just play whack a mole with the cancers when they arise. So you get to live two or three times as long but you're in for cancer removal at least once per decade.
The previous line actually sheds more light on this: "As with all immunosuppressive medications, in theory, sirolimus may decrease the body's inherent anticancer activity and allow some cancers that would have been naturally destroyed to proliferate."