> I ask you to set something up for me. I don't ask you to setup something for me.
"Please set up a meeting with Kevin for me" sounds more natural to me than "Please set a meeting with Kevin up for me."
"Please set up a meeting with Kevin for me" sounds more natural to me than "Please set a meeting with Kevin up for me."
An example (pronouns almost never qualify as "heavy"):
Good:
• Please set him up
Weird sounding:
• *Please set up him